Journal ArticleDOI
A Metabolic Multistage Glutathione Depletion Used for Tumor-Specific Chemodynamic Therapy.
TLDR
A multistage GSH-consuming and tumor-specific CDT that fabricates nanomedicine with GSH exhausted function for highly potent CDT but also uses metabolic differences to achieve tumor- specific therapy.Abstract:
The high glutathione (GSH) content in tumor cells strongly affects the efficiency of chemodynamic therapy (CDT). Despite devoted efforts, it still remains a formidable challenge for manufacturing a tumor-specific CDT with rapid and thorough depletion of GSH. Herein, a multistage GSH-consuming and tumor-specific CDT is presented. By consuming the reserved GSH and inhibiting both the raw materials and energy supply of GSH synthesis in cancer cells, it achieves highly potent GSH exhaustion. Our used glycolysis inhibitor cuts off the specific glycolysis of tumor cells to increase the sensitivity to CDT. Furthermore, the starvation effect of glycolysis inhibitor can stimulate the protective mode of normal cells. Since the glycolysis inhibitor and nanocarrier are responsive to tumor microenvironment, this makes CDT more selective to tumor cells. Our work not only fabricates nanomedicine with GSH exhausted function for highly potent CDT but also uses metabolic differences to achieve tumor-specific therapy.read more
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Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy.
Xingyu Hou,Dan Zhong,Hongying Chen,Zhongwei Gu,Qiyong Gong,Xuelei Ma,Hui Zhang,Hongyan Zhu,Kui Luo +8 more
TL;DR: In this paper , the authors overviewed the biological function and multiple chemical modifications of hyaluronic acid (HA) and discussed the fabrication of HA-based drug delivery systems (HA-DDSs) with specific tumor microenvironmental stimuli-responsive linkers.
Journal ArticleDOI
Tumor Microenvironment-Adaptive Nanoplatform Synergistically Enhances Cascaded Chemodynamic Therapy
Yuemin Wang,Duan Wang,Yuyue Zhang,Hong Xu,Luxuan Shen,Jing Cheng,Xinyuan Xu,Hong Qing Tan,Xingyu Chen,Jianshu Li +9 more
TL;DR: Wang et al. as discussed by the authors used mesoporous Fe3O4 nanoparticles loaded with perfluoropentane (PFP) and glucose oxidase (GOx) as a tumor microenvironment-adaptive nanoplatform.
Journal ArticleDOI
Hydrogen peroxide self-sufficient and glutathione-depleted nanoplatform for boosting chemodynamic therapy synergetic phototherapy.
TL;DR: In this article , a versatile nanoplatform MgO2@SnFe2O4@PEG (MSnFeP) is elaborately fabricated for boosting CDT synergetic phototherapy.
Journal ArticleDOI
Targeted Delivery of Chemo‐Sonodynamic Therapy via Brain Targeting, Glutathione‐Consumable Polymeric Nanoparticles for Effective Brain Cancer Treatment
TL;DR: Treatment with LiPTD NPs effectively inhibits tumor growth and prolongs the survival of tumor‐bearing mice, and may suggest a potential new approach for effective GBM treatment.
Journal ArticleDOI
Biomolecule-Based Circularly Polarized Luminescent Materials: Construction, Progress, and Applications.
TL;DR: In this article , the latest progress in circularly polarized luminescence (CPL) materials based on biomolecules is reviewed, including the chiral construction of bio-based CPL materials and their emerging applications.
References
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Journal ArticleDOI
Glutathione: overview of its protective roles, measurement, and biosynthesis.
TL;DR: The purpose here is to provide a brief overview of some of the important aspects of glutathione metabolism as part of this special issue that will provide a more comprehensive review of the state of knowledge regarding this essential molecule.
Journal ArticleDOI
Targeting mitochondria for cancer therapy
Simone Fulda,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Guido Kroemer,Guido Kroemer +6 more
TL;DR: The mitochondrial metabolism of cancer cells is deregulated owing to the use of glycolytic intermediates, which are normally destined for oxidative phosphorylation, in anabolic reactions and activation of the cell death machinery by stimulating mitochondrial membrane permeabilization could therefore be promising therapeutic approaches.