Glutathione: overview of its protective roles, measurement, and biosynthesis.
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TLDR
The purpose here is to provide a brief overview of some of the important aspects of glutathione metabolism as part of this special issue that will provide a more comprehensive review of the state of knowledge regarding this essential molecule.About:
This article is published in Molecular Aspects of Medicine.The article was published on 2009-02-01 and is currently open access. It has received 1576 citations till now. The article focuses on the topics: Glutathione.read more
Citations
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Glutathione metabolism in cancer progression and treatment resistance.
Ankita Bansal,M. Celeste Simon +1 more
TL;DR: Recent studies that focus on deciphering the role of GSH in tumor initiation and progression as well as mechanisms underlying how GSH imparts treatment resistance to growing cancers are discussed.
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Apoptosis and glutathione: beyond an antioxidant
Rodrigo Franco,John A. Cidlowski +1 more
TL;DR: This work reformulates emerging paradigms of apoptotic cell death into current understanding of cell death mechanisms and suggests that GSH depletion and post-translational modifications of proteins through glutathionylation are critical regulators of apoptosis.
Journal ArticleDOI
Glutathione: new roles in redox signaling for an old antioxidant
TL;DR: This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.
Journal ArticleDOI
Chemistry and biochemistry of lipid peroxidation products.
Françoise Guéraud,Mustafa Atalay,N. Bresgen,Ana Čipak,Peter Eckl,Laurence Huc,Isabelle Jouanin,Werner Siems,Koji Uchida +8 more
TL;DR: New advances regarding apoptosis induction, survival/proliferation processes and autophagy regulated by 4-hydroxynonenal, a major product of omega-6 fatty acid peroxidation, in relationship with detoxication mechanisms are related.
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The Redox Stress Hypothesis of Aging
Rajindar S. Sohal,William C. Orr +1 more
TL;DR: The main objective of this review is to examine the role of endogenous reactive oxygen/nitrogen species (ROS) in the aging process and proposes the "redox stress hypothesis", which proposes that aging-associated functional losses are primarily caused by a progressive pro-oxidizing shift in the redox state of the cells, which leads to the overoxidation of redox-sensitive protein thiols and the consequent disruption of theredox-regulated signaling mechanisms.
References
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Journal ArticleDOI
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
Journal ArticleDOI
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Ken Itoh,Nobunao Wakabayashi,Yasutake Katoh,Tetsuro Ishii,Kazuhiko Igarashi,James Douglas Engel,James Douglas Engel,Masayuki Yamamoto +7 more
TL;DR: It is postulate that Keap1 and Nrf2 constitute a crucial cellular sensor for oxidative stress, and together mediate a key step in the signaling pathway that leads to transcriptional activation by this novel NRF2 nuclear shuttling mechanism.
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Regulation of glutathione synthesis
TL;DR: Dysregulation of GSH synthesis is increasingly being recognized as contributing to the pathogenesis of many pathological conditions, including diabetes mellitus, pulmonary fibrosis, cholestatic liver injury, endotoxemia and drug-resistant tumor cells.
Book ChapterDOI
Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples.
TL;DR: The sum of the reduced and oxidized forms of glutathione can be determined by using a kinetic assay in which catalytic amounts of GSH or GSSG and glutATHione reductase bring about the continuous reduction of 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB) by nicotinamide adenine dinucleotide phosphate (NADPH).