Journal ArticleDOI
A new lectin family with structure similarity to actinoporins revealed by the crystal structure of Xerocomus chrysenteron lectin XCL
Catherine Birck,Luminita Damian,Claire Marty-Detraves,Andrée Lougarre,Clemens Schulze-Briese,Patrice Koehl,Didier Fournier,Laurent Paquereau,Jean-Pierre Samama +8 more
TLDR
The specific structural features and sequence signatures in each protein family suggest a potential sugar binding site in XCL and a possible evolutionary relationship between these proteins.About:
This article is published in Journal of Molecular Biology.The article was published on 2004-12-10. It has received 66 citations till now. The article focuses on the topics: C-type lectin & Protein family.read more
Citations
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Journal ArticleDOI
Human Antimicrobial Peptides and Proteins
TL;DR: It appears that granulysin enters cells and kills intracellular pathogens with the aid of pore-forming perforin, opening new avenues to the development of anti-infectious drugs.
Journal ArticleDOI
A common toxin fold mediates microbial attack and plant defense
Christian Ottmann,Borries Luberacki,Isabell Küfner,Wolfgang Koch,Frédéric Brunner,Michael Weyand,Laura Mattinen,Minna Pirhonen,Gregor Anderluh,Hanns Ulrich Seitz,Thorsten Nürnberger,Claudia Oecking +11 more
TL;DR: NLP mutant protein analyses revealed that identical structural properties were required to cause plasma membrane permeabilization and cytolysis in plant cells, as well as to restore bacterial virulence, suggesting that toxin-mediated interference with host integrity triggers plant immunity-associated responses.
Journal ArticleDOI
Molecular Determinants of Sphingomyelin Specificity of a Eukaryotic Pore-forming Toxin *
Biserka Bakrač,Ion Gutiérrez-Aguirre,Zdravko Podlesek,Andreas F.-P. Sonnen,Robert J.C. Gilbert,Peter Maček,Jeremy H. Lakey,Gregor Anderluh +7 more
TL;DR: The molecular basis of SM recognition by the membrane-binding eukaryotic cytolysin equinatoxin II (EqtII) is revealed and it is shown that the discrimination between sphingomyelin and phosphatidylcholine occurs in the region directly below the phosphorylcholine headgroup.
Journal ArticleDOI
Molecular mechanism of pore formation by actinoporins.
TL;DR: Recent sequence and structural data of proteins similar to actinoporins indicate that they are not a unique family restricted to sea anemones as was long believed and it is hypothesised that AF domain proteins are peripheral membrane proteins.
Journal ArticleDOI
Evidence for functional diversification within a fungal NEP1-like protein family.
Parthasarathy Santhanam,H. Peter van Esse,Isabell Albert,Luigi Faino,Thorsten Nürnberger,Bart P. H. J. Thomma +5 more
TL;DR: It is demonstrated that the expanded V. dahliae NLP family shows functional diversification, revealing not only differential cytotoxicity between family members but also that the cytotoxic NLP play a role in vegetative growth and asexual reproduction in addition to their contribution to virulence.
References
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Journal ArticleDOI
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Stephen F. Altschul,Thomas L. Madden,Alejandro A. Schäffer,Jinghui Zhang,Zheng Zhang,Webb Miller,David J. Lipman +6 more
TL;DR: A new criterion for triggering the extension of word hits, combined with a new heuristic for generating gapped alignments, yields a gapped BLAST program that runs at approximately three times the speed of the original.
Journal ArticleDOI
Clustal w: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
TL;DR: The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved and modifications are incorporated into a new program, CLUSTAL W, which is freely available.
Book ChapterDOI
Processing of X-ray diffraction data collected in oscillation mode
Zbyszek Otwinowski,Wladek Minor +1 more
TL;DR: The methods presented in the chapter have been applied to solve a large variety of problems, from inorganic molecules with 5 A unit cell to rotavirus of 700 A diameters crystallized in 700 × 1000 × 1400 A cell.
Journal ArticleDOI
PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
Journal ArticleDOI
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Axel T. Brunger,Axel T. Brunger,Paul D. Adams,G M Clore,W. L. DeLano,Piet Gros,R.W. Grosse-Kunstleve,R.W. Grosse-Kunstleve,Jiansheng Jiang,J. Kuszewski,Michael Nilges,Navraj S. Pannu,Randy J. Read,Luke M. Rice,Thomas Simonson,Gregory L. Warren +15 more
TL;DR: The Crystallography & NMR System (CNS) as mentioned in this paper is a software suite for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy.