Journal ArticleDOI
A New Single 808 nm NIR Light‐Induced Imaging‐Guided Multifunctional Cancer Therapy Platform
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TLDR
The multifunctional cancer therapy platform with multimode imaging effects realizes a true sense of light‐induced imaging‐guided cancer therapy.Abstract:
The NIR light-induced imaging-guided cancer therapy is a promising route in the targeting cancer therapy field. However, up to now, the existing single-modality light-induced imaging effects are not enough to meet the higher diagnosis requirement. Thus, the multifunctional cancer therapy platform with multimode light-induced imaging effects is highly desirable. In this work, captopril stabilized-Au nanoclusters Au25(Capt)18−(Au25) are assembled into the mesoporous silica shell coating outside of Nd3+-sensitized upconversion nanoparticles (UCNPs) for the first time. The newly formed Au25 shell exhibits considerable photothermal effects, bringing about the photothermal imaging and photoacoustic imaging properties, which couple with the upconversion luminescence imaging. More importantly, the three light-induced imaging effects can be simultaneously achieved by exciting with a single NIR light (808 nm), which is also the triggering factor for the photothermal and photodynamic cancer therapy. Besides, the nanoparticles can also present the magnetic resonance and computer tomography imaging effects due to the Gd3+ and Yb3+ ions in the UCNPs. Furthermore, due to the photodynamic and the photothermal effects, the nanoparticles possess efficient in vivo tumor growth inhibition under the single irradiation of 808 nm light. The multifunctional cancer therapy platform with multimode imaging effects realizes a true sense of light-induced imaging-guided cancer therapy.read more
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Recent advances in functional nanomaterials for light–triggered cancer therapy
TL;DR: An in–depth review of major breakthroughs in recent advanced functional nanomaterials for photo–triggered therapy is presented, and an outlook of the future directions of the rapidly growing functional nanomechanical directions is given.
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Plasmonic Photothermal Nanoparticles for Biomedical Applications
TL;DR: This Progress Report summarizes recent advances in the understanding and applications of plasmonic photothermal nanoparticles, particularly for sensing, imaging, therapy, and drug delivery, and discusses the future directions of these fields.
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Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications.
Nana Zhao,Liemei Yan,Xiaoyi Zhao,Xinyan Chen,Aihua Li,Di Zheng,Xin Zhou,Xiaoguang Dai,Fu-Jian Xu +8 more
TL;DR: The design, properties, and biomedical applications of organic/inorganic nanohybrids fabricated from inorganic nanoparticles and polymers, including properties from organic and inorganic parts, synergistic properties, morphology-dependent Properties, and self-assembly of nanohYbrids are reviewed.
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Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy
Ruiyun Zhang,Ruirui Xing,Ruirui Xing,Tifeng Jiao,Kai Ma,Chengjun Chen,Guanghui Ma,Xuehai Yan +7 more
TL;DR: The rationale of these pure nanodrugs via the self-assembly approach might open an alternative avenue and give inspiration to fabricate new carrier-free nanodruggeds for tumor theranostics, especially for two small molecular antitumor drugs with the aim of combinational antitumors therapy in a synergistic way.
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808‐nm‐Light‐Excited Lanthanide‐Doped Nanoparticles: Rational Design, Luminescence Control and Theranostic Applications
TL;DR: In this review, the progress of 808 nm-excited LnNPs is reported, including their i) luminescence mechanism, ii) Luminescence enhancement, iii) color tuning, iv) diagnostic and v) therapeutic applications.
References
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Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
TL;DR: It is found that, after exposure to continuous red laser at 800 nm, malignant cells require about half the laser energy to be photothermally destroyed than the nonmalignant cells, so both efficient cancer cell diagnostics and selective photothermal therapy are realized at the same time.
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Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging
TL;DR: Functional photoacoustic microscopy (fPAM) is reported, which provides multiwavelength imaging of optical absorption and permits high spatial resolution beyond this depth limit with a ratio of maximum imaging depth to depth resolution greater than 100.
Journal ArticleDOI
Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery
TL;DR: Carbon nanotubes exhibit many unique intrinsic physical and chemical properties and have been intensively explored for biological and biomedical applications in the past few years as mentioned in this paper, and a comprehensive review of the main results from our and other groups in this field can be found in this paper.
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Upconversion nanophosphors for small-animal imaging
Jing Zhou,Zhuang Liu,Fuyou Li +2 more
TL;DR: In this critical review, recent reports regarding the synthesis of water-soluble UCNPs and their surface modification and bioconjugation chemistry are summarized and the applications ofUCNPs for small-animal imaging, including tumor-targeted imaging, lymphatic imaging, vascular imaging and cell tracking are reviewed in detail.
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Near-Infrared Resonant Nanoshells for Combined Optical Imaging and Photothermal Cancer Therapy
TL;DR: Metal nanoshells were designed that possess both absorption and scattering properties in the NIR to provide optical contrast for improved diagnostic imaging and, at higher light intensity, rapid heating for photothermal therapy.