Journal ArticleDOI
A niclosamide–tobramycin hybrid adjuvant potentiates cefiderocol against P. aeruginosa
Liam Berry,Marc Brizuela,Gregory Jackson,Frank Schweizer +3 more
- Vol. 12, Iss: 9, pp 1565-1573
TLDR
Results indicate that a niclosamide-tobramycin hybrid adjuvant can serve to potentiate a newly approved antibiotic.Abstract:
There is an urgent need for new therapies to overcome antimicrobial resistance (AMR) especially against Gram-negative bacilli (GNB). Multicomponent therapy combining antibiotics with enhancer molecules known as adjuvants is an emerging strategy to combat AMR. We have previously reported tobramycin-based adjuvants which are able to potentiate various antibiotics. In order to expand the repertoire of tobramycin hybrid adjuvants, a new hybrid containing niclosamide, an FDA approved anthelmintic which has recently demonstrated a variety of interesting biological effects, was synthesized. It was found that this conjugate can potentiate several antibiotics against multidrug-resistant GNB, including the recently approved siderophore cephalosporin cefiderocol. 8 μg ml-1 of the niclosamide-tobramycin hybrid in combination therapy against a pandrug-resistant strain of P. aeruginosa was able to lower the cefiderocol MIC 32-fold, from 8 μg ml-1 to 0.25 μg ml-1 in iron-rich media where siderophore uptake is reduced. These results indicate that a niclosamide-tobramycin hybrid adjuvant can serve to potentiate a newly approved antibiotic.read more
Citations
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Journal ArticleDOI
Anthelmintic drugs for repurposing against Gram-negative bacilli infections.
TL;DR: The goal of this review is to provide an overview of the scientific evidence on potential anthelmintic drugs targeting Gram-negative bacilli (GNB) and highlight the potential of anthel Mintic drugs for treatments of GNB infections.
Journal ArticleDOI
Repurposing Anthelmintics: Rafoxanide- and Copper-Functionalized SBA-15 Carriers against Methicillin-Resistant Staphylococcus aureus.
Maricely Ramírez-Hernandez,Javiera Norambuena,Hongnan Hu,Belvin Thomas,Chaoyun Tang,Jeffrey M. Boyd,Tewodros Asefa +6 more
TL;DR: In this paper , the synthesis of amine-functionalized SBA-15 mesoporous silica nanomaterials with physisorbed rafoxanide (RFX), a commonly used salicylanilide anthelmintic, and anchored Cu(II) ions that exhibit enhanced antimicrobial efficacy against the pathogenic bacterium Staphylococcus aureus was presented.
References
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Journal ArticleDOI
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Journal ArticleDOI
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