A novel characterization technique for superparamagnetic iron oxide nanoparticles: The superparamagnetic quantifier, compared with magnetic particle spectroscopy.
M. M. van de Loosdrecht,Sebastian Draack,Sebastiaan Waanders,J. G.L. Schlief,Hendrikus J.G. Krooshoop,Thilo Viereck,Frank Ludwig,B. ten Haken +7 more
TLDR
Both the SPaQ and MPS are highly suited to improve understanding SPION behavior, which will lead to the radical improvement of sentinel node biopsy accuracy.Abstract:
Superparamagnetic iron oxide nanoparticles (SPIONs) are used as a tracer material in sentinel node biopsies. The latter is a procedure to analyze if cancer cells have spread to lymph nodes, helping to personalize patient care. To predict SPION behavior in vivo, it is important to analyze their magnetic properties in biological environments. The superparamagnetic quantifier (SPaQ) is a new device to measure the dynamic magnetization curve of SPIONs. The magnetization curve was measured for two types of SPIONs: Resovist and SHP-25. We used three techniques: Vibrating Sample Magnetometry (VSM), Magnetic Particle Spectroscopy (MPS), and our new SPaQ. Furthermore, AC susceptibility (ACS) measurements were performed as part of the evaluation of the three techniques. SPaQ and VSM results were found to be similar. Measurement results were nearly identical in both directions, indicating minor hysteresis. However, in MPS measurements, a clear hysteresis loop was observed. Furthermore, the ACS measurements showed a pronounced Brownian maximum, indicating an optimal response for an AC frequency below 10 kHz for both particle systems. Both the SPaQ and MPS were found to be superior to VSM since measurements are faster, can be performed at room temperature, and are particularly sensitive to particle dynamics. The main difference between the SPaQ and MPS lies in the excitation sequence. The SPaQ combines an alternating magnetic field that has a low amplitude with a gradual DC offset, whereas MPS uses only an alternating field that has a large amplitude. In conclusion, both the SPaQ and MPS are highly suited to improve understanding SPION behavior, which will lead to the radical improvement of sentinel node biopsy accuracy.read more
Citations
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Magnetic Particle Spectroscopy: A Short Review of Applications Using Magnetic Nanoparticles
TL;DR: Magnetic particle spectroscopy (MPS) also called magnetization response spectroscope (MRS) is a versatile measurement tool derived from magnetic particle imaging (MPI) as discussed by the authors.
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Magnetic Particle Spectroscopy: A Short Review of Applications
TL;DR: This short review highlights some of the representative applications based on MPS platform, thereby providing a roadmap of this technology and the insights for researchers in this area.
Journal ArticleDOI
Introducing Specificity to Iron Oxide Nanoparticle Imaging by Combining 57Fe-Based MRI and Mass Spectrometry
Max Masthoff,Rebecca Buchholz,Andre Beuker,Lydia Wachsmuth,Alexander Kraupner,Franziska Albers,Felix Noah Freppon,Anne Helfen,Mirjam Gerwing,Carsten Höltke,Uwe Hansen,Jan Rehkämper,Torsten Vielhaber,Walter Heindel,Michel Eisenblätter,Uwe Karst,Moritz Wildgruber,Cornelius Faber +17 more
TL;DR: This approach combines non-radioactive 57Fe-ION MRI with ex vivo laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging, enabling unambiguous differentiation between endogenous iron (56Fe) and iron originating from applied ION in mice.
Journal ArticleDOI
Fabrication and preliminary evaluation of alginate hydrogel-based magnetic springs with actively targeted heating and drug release mechanisms for cancer therapy
TL;DR: In this paper , a calcium alginate hydrogel-based magnetic spring containing magnetically aligned Fe2O3 magnetic nanoparticles (MNPs) was developed to render them responsive toward magnetic fields.
Journal ArticleDOI
Assessment of differential magnetic susceptibility in nanoparticles: Effects of changes in viscosity and immobilisation
TL;DR: A superparamagnetic quantifier (SPaQ) is used here to assess the differential magnetic susceptibility of three commercially available SPIONs: Synomag®, Resovist® and Sienna+®, which appears to be a promising candidate for clinical applications due to its low sensitivity to changes in viscosity.
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