A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement
TLDR
The aim of the present work was to improve the interfacial adhesion between fibers and matrix to obtain tougher biocompatible fiber-reinforced calcium phosphate cements (FRCPCs), which resulted in an increase of the work of fracture (several hundred-fold increase), while the elastic modulus and bending strength were maintained similar to the materials without additives.Abstract:
Calcium phosphate cements (CPCs) are extensively used as synthetic bone grafts, but their poor toughness limits their use to non-load-bearing applications. Reinforcement through introduction of fibers and yarns has been evaluated in various studies but always resulted in a decrease in elastic modulus or bending strength when compared to the CPC matrix. The aim of the present work was to improve the interfacial adhesion between fibers and matrix to obtain tougher biocompatible fiber-reinforced calcium phosphate cements (FRCPCs). This was done by adding a polymer solution to the matrix, with chemical affinity to the reinforcing chitosan fibers, namely trimethyl chitosan (TMC). The improved wettability and chemical affinity of the chitosan fibers with the TMC in the liquid phase led to an enhancement of the interfacial adhesion. This resulted in an increase of the work of fracture (several hundred-fold increase), while the elastic modulus and bending strength were maintained similar to the materials without additives. Additionally the TMC-modified CPCs showed suitable biocompatibility with an osteoblastic cell line.read more
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References
More filters
Journal ArticleDOI
Quantitative interpretation of X-ray diffraction patterns of mixtures. II. Adiabatic principle of X-ray diffraction analysis of mixtures
TL;DR: In this article, the matrix-flushing theory and the adiabatic principle were applied in applied X-ray diffraction analysis to obtain the quantitative composition of a mixture.
Journal ArticleDOI
The mechanical properties of bone tissue in children.
John D. Currey,G Butler +1 more
TL;DR: Compared with the bone of adults, that of children had a lower modulus of elasticity, a lower bending strength, and a lower ash content, but the children's bone deflected more and absorbed more energy before breaking.
Journal ArticleDOI
A Biopolymer Chitosan and Its Derivatives as Promising Antimicrobial Agents against Plant Pathogens and Their Applications in Crop Protection
TL;DR: In this paper, the authors present an overview of the antimicrobial effects, mechanisms, and applications of a biopolymer chitosan and its derivatives in crop protection, and take a closer look at the physiochemical properties and chemical modifications of chitosa molecule.
Journal ArticleDOI
New method for the quaternization of chitosan
TL;DR: In this article, the role of sodium iodide as an electrostatic charges screening salt is discussed, and the reaction was performed in several steps to obtain derivatives of chitosan at various degrees of quaternization with a limit value near 64%.
Journal ArticleDOI
Injectable and macroporous calcium phosphate cement scaffold.
TL;DR: The injectability of a ceramic scaffold, a macroporous CPC, was studies for the first time and may be useful in surgical sites that are not freely accessible by open surgery or when using minimally invasive techniques.
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