Journal ArticleDOI
A nuclear cap binding protein complex involved in pre-mRNA splicing
Elisa Izaurralde,Joe Lewis,C. McGuigan,Marzena Jankowska,Edward Darzynkiewicz,Iain W. Mattaj +5 more
TLDR
Analysis of the inhibition of pre-mRNA splicing in vitro and in vivo by chemically modified analogs of the cap structure, and of the binding of these analogs to CBC in vitro, suggests a role for the complex in splicing.About:
This article is published in Cell.The article was published on 1994-08-26. It has received 497 citations till now. The article focuses on the topics: Protein splicing & Exonic splicing enhancer.read more
Citations
More filters
Journal ArticleDOI
CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
TL;DR: It is concluded that CRM1 is an export receptor for leucine-rich nuclear export signals and a model for the role of RanGTP inCRM1 function and in nuclear export in general is discussed.
Journal ArticleDOI
Transport between the cell nucleus and the cytoplasm.
Dirk Görlich,Ulrike Kutay +1 more
TL;DR: A focus of this review is nuclear export of messenger RNA, which apparently largely relies on export mediators distinct from importin beta-related factors.
Journal ArticleDOI
Nucleocytoplasmic Transport: The Soluble Phase
Iain W. Mattaj,Ludwig Englmeier +1 more
TL;DR: Directionality of either import or export depends on association between a substrate and its receptor on one side of the nuclear envelope and dissociation on the other, and the Ran GTPase is critical in generating this asymmetry.
Journal ArticleDOI
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics
TL;DR: The acquisition and loss of mRNA-associated proteins accompanies the transition from the pioneer round to subsequent rounds of translation, and from translational competence to substrate for nonsense-mediated mRNA decay.
Journal ArticleDOI
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs.
TL;DR: The Rev activation domain constitutes a nuclear export signal that redirects RRE-containing viral RNAs to a non-mRNA export pathway.
References
More filters
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
Book
Antibodies: A Laboratory Manual
Ed Harlow,David P. Lane +1 more
TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
Book
PCR protocols : A guide to methods and applications
TL;DR: Basic Methodology: M.A. Innis and D.F. Frohman, RACE: Rapid Amplification of cDNA Ends, and RNA Processing: Apo-B.R. Kwok, Procedure to Minimuze PCR-Product Carry-Over.
Related Papers (5)
Monomethylated cap structures facilitate RNA export from the nucleus.
Jörg Hamm,Iain W. Mattaj +1 more