Journal ArticleDOI
A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection.
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It is concluded that a novel membrane protein determines susceptibility to ecotropic MuLV infection by binding and/or fusion with the virus envelope.About:
This article is published in Cell.The article was published on 1989-05-19. It has received 683 citations till now. The article focuses on the topics: Complementary DNA & Ecotropism.read more
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Hepatitis B Virus Biology
TL;DR: The state of knowledge in this very active field of hepatitis B viruses is reviewed with an emphasis on past accomplishments as well as goals for the future.
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Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
Homayoun Vaziri,Samuel Benchimol +1 more
TL;DR: Results show that retroviral-mediated expression of hTERT resulted in functional telomerase activity in normal aging human cells, indicating that telomere length is one factor that can determine the replicative life span of human cells.
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Molecular machinery for non-vesicular trafficking of ceramide
Kentaro Hanada,Keigo Kumagai,Satoshi Yasuda,Yukiko Miura,Miyuki Kawano,Masayoshi Fukasawa,Masahiro Nishijima +6 more
TL;DR: It is concluded that CERT mediates the intracellular trafficking of ceramide in a non-vesicular manner.
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Biochemical evidence that Patched is the Hedgehog receptor
TL;DR: Binding studies using labelled Shh that strongly suggest that the Hh receptor is encoded by patched (ptc), a gene first identified in genetic screens in Drosophila4.
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Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.
TL;DR: Cloning of a cDNA encoding the inducible nitric oxide synthase from a murine macrophage cell line, RAW264.7, exposed to interferon-gamma and lipopolysaccharide, identifies shared binding sites for the cofactors NADPH and flavins in the C-terminal half of both proteins and an additional conserved region near the N terminus that may recognize L-arginine and/or contribute to the active site.
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DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
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A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
TL;DR: A technique for conveniently radiolabeling DNA restriction endonuclease fragments to high specific activity is described, and these "oligolabeled" DNA fragments serve as efficient probes in filter hybridization experiments.
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A simple method for displaying the hydropathic character of a protein
Jack Kyte,Russell F. Doolittle +1 more
TL;DR: A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised and its simplicity and its graphic nature make it a very useful tool for the evaluation of protein structures.
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
TL;DR: In this article, a technique for conveniently radiolabeling DNA restriction endonuclease fragments to high specific activity is described, where DNA fragments are purified from agarose gels directly by ethanol precipitation and are then denatured and labeled with the large fragment of DNA polymerase I, using random oligonucleotides as primers.
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A comprehensive set of sequence analysis programs for the VAX
TL;DR: A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system.