Journal ArticleDOI
A reinvestigation of the reactions of 3-substituted chromones with hydroxylamine. Unexpected synthesis of 3-amino-4H-chromeno[3,4-d]isoxazol-4-one and 3-(diaminomethylene)chroman-2,4-dione
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TLDR
In this paper, a proof of structures and a probable reaction pathway for 3-substituted chromones with hydroxylamine in alkaline medium were presented, and a possible reaction pathway was presented for 3-(diaminomethylene)chroman-2,4-dione.About:
This article is published in Tetrahedron Letters.The article was published on 2008-11-24. It has received 43 citations till now. The article focuses on the topics: Hydroxylamine.read more
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Coumarin heterocyclic derivatives: chemical synthesis and biological activity
Fernanda G. Medina,Joaquín G. Marrero,Mariana Macías-Alonso,Magdalena C. Gonzalez,Iván Córdova-Guerrero,Ariana G. Teissier Garcia,Soraya Osegueda-Robles +6 more
TL;DR: This review highlights the broad range of science that has arisen from the synthesis of coumarin-linked and fused heterocycle derivatives and their synthesis and biological activity.
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2,3-Unsubstituted chromones and their enaminone precursors as versatile reagents for the synthesis of fused pyridines
Viktor O. Iaroshenko,Viktor O. Iaroshenko,Satenik Mkrtchyan,Ashot Gevorgyan,Ashot Gevorgyan,Mariia Miliutina,Alexander Villinger,Dmytro Volochnyuk,Vyacheslav Ya. Sosnovskikh,Peter Langer +9 more
TL;DR: A divergent and regioselective approach to fused pyridines was developed through formal [3 + 3] cyclocondensations from simple 2,3-unsubstituted chromones or their enaminone precursors.
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Synthesis, spectral characterization and biological evaluation of some copper(II) complexes containing 4-oxo-4H-chromene-3-carbaldehyde-4(N)-substituted thiosemicarbazones
TL;DR: The new water soluble chromone appended copper(II) complexes have shown significant growth inhibitory activity against selected types of bacteria and fungi and overcome cisplatin resistance in the MCF-7 and A549 cell lines.
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One-pot five-component synthesis of spirocyclopenta[b]chromene derivatives and their acid-catalyzed rearrangement.
Michael A. Terzidis,Tryfon Zarganes-Tzitzikas,Constantinos Tsimenidis,Julia Stephanidou-Stephanatou,Constantinos A. Tsoleridis,George E. Kostakis +5 more
TL;DR: The structure elucidation of the products was accomplished by 1D and 2D NMR experiments and confirmed by X-ray crystallographic analysis, and full assignment of all (1)H and (13)C NMR chemical shifts has been unambiguously achieved with the aid of DFT/GIAO calculations.
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Structural studies and characterization of 3-formylchromone and products of its reactions with chosen primary aromatic amines
TL;DR: In this article, the crystal structure and FTIR spectrum of 3-formylchromone have been analyzed and a new organic ligands, 3-(anilinomethylene)-2-methoxychroman-4-one (1) and 3-(1′,4′-benzodioxan-6′-aminomethane)-2methoxidechroman4-1 (2) were synthesized.
References
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Book
Comprehensive Heterocyclic Chemistry II
TL;DR: In this article, the CHEC III is organized in 15 volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three and four-membered heterocycles, together with all fused systems containing a three- or four-measured heterocyclic ring.
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The combinatorial synthesis of bicyclic privileged structures or privileged substructures
TL;DR: Privileged substructures are believed to achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns.
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Studies on antianaphylactic agents—III
TL;DR: By the application of the Vilsmeier-Haack reaction to various o-hydroxyacetophenone derivatives, 4-oxo-4H-1-benzopyran-3-carboxaldehydes were synthesized in one step as discussed by the authors.
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Studies on antianaphylactic agents. 5. Synthesis of 3-(1H-tetrazol-5-yl)chromones, a new series of antiallergic substances.
TL;DR: A number of 3-(1H-tetrazol-5-yl)chromones were synthesized and found to have antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test and are of possible value for the treatment of asthma.