Journal ArticleDOI
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure.
Joohee Kim,Jihun Park,Young Geun Park,Young Geun Park,Eunkyung Cha,Minjae Ku,Hyeon Seok An,Kyoung-Pil Lee,Man-Il Huh,Junmo Kim,Taek-Soo Kim,Dai Woo Kim,Hong Kyun Kim,Jang Ung Park +13 more
TLDR
In this paper, a soft and transparent contact lens for the quantitative monitoring of intraocular pressure (IOP) in real time using a smartphone was proposed, and tested in humans and rabbits.Abstract:
Continuous detection of raised intraocular pressure (IOP) could benefit the monitoring of patients with glaucoma. Current contact lenses with embedded sensors for measuring IOP are rigid, bulky, partially block vision or are insufficiently sensitive. Here, we report the design and testing in volunteers of a soft and transparent contact lens for the quantitative monitoring of IOP in real time using a smartphone. The contact lens incorporates a strain sensor, a wireless antenna, capacitors, resistors, stretchable metal interconnects and an integrated circuit for wireless communication. In rabbits, the lens provided measurements that match those of a commercial tonometer. In ten human participants, the lens proved to be safe, and reliably provided accurate quantitative measurements of IOP without inducing inflammation.read more
Citations
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Technology Roadmap for Flexible Sensors.
Yi Fei Luo,Mohammad Reza Abidian,Jong Hyun Ahn,Deji Akinwande,Anne M. Andrews,Markus Antonietti,Zhenan Bao,Magnus Berggren,Christopher Berkey,Christopher J. Bettinger,Jun Chen,Peng Fei Chen,Wenlong Cheng,Xu Cheng,Seon-Jin Choi,Alex Chortos,Canan Dagdeviren,Reinhold H. Dauskardt,Chong-an Di,Michael D. Dickey,Xiangfeng Duan,Antonio Facchetti,Zhiyong Fan,Yin Fang,Jianyou Feng,Xue Feng,Huajian Gao,Wei Gao,Xiwen Gong,Chuan Fei Guo,Xiao Ling Guo,Martin C. Hartel,Zihan He,John S. Ho,Youfan Hu,Qiyao Huang,Yu Huang,Fengwei Huo,M. M. Hussain,Ali Javey,Unyong Jeong,Chen Jiang,Xingyu Jiang,Jiheong Kang,Daniil Karnaushenko,Ali Khademhosseini,Dae-Hyeong Kim,Il-Doo Kim,Dmitry Kireev,Lingxuan Kong,Chengkuo Lee,Nae-Eung Lee,Pooi See Lee,Tae-Woo Lee,Fengyu Li,Jinxing Li,Cuiyuan Liang,Chwee Teck Lim,Yuanjing Lin,Darren J. Lipomi,Jia Liu,Kai Liu,Nan Liu,Ren Liu,Yuxin Liu,Yuxuan Liu,Zhiyuan Liu,Zhuangjian Liu,Xian Jun Loh,Nanshu Lu,Zhi-Mei Lv,Shlomo Magdassi,George G. Malliaras,Naoji Matsuhisa,Arokia Nathan,Simiao Niu,Jieming Pan,Changhyun Pang,Qibing Pei,Huisheng Peng,Dianpeng Qi,Huaying Ren,John A. Rogers,Aaron W. Rowe,Oliver G. Schmidt,Tsuyoshi Sekitani,Dae-Gyo Seo,Guozhen Shen,Xing Sheng,Qiongfeng Shi,Takao Someya,Yanlin Song,Eleni Stavrinidou,Meng Su,Xuemei Sun,Kuniharu Takei,Xiaoming Tao,Benjamin C. K. Tee,A. Thean,Tran Quang Trung,Changjin Wan,Huiliang Wang,Joseph Wang,Ming Wei Wang,Si-Xian Wang,Ting Wang,Zhong Lin Wang,Paul S. Weiss,Hanqi Wen,Sheng Xu,Tailin Xu,Hongping Yan,Xuzhou Yan,Hui Yang,Le Yang,Shuaijian Yang,Lan Yin,Cunjiang Yu,Gui-Yun Yu,Jing Yu,Shu-Hong Yu,Xinge Yu,E. G. Zamburg,Haixia Zhang,XiangYu Zhang,Xiao-Sheng Zhang,Xueji Zhang,Yihui Zhang,Yu Zhang,Siyuan Zhao,Xuanhe Zhao,Yuanjin Zheng,Yu-Qing Zheng,Zijian Zheng,Tao Zhou,Bowen Zhu,Ming Zhu,Rong Zhu,Yangzhi Zhu,Yong-Guan Zhu,Guijin Zou,Xiaodong Chen +141 more
TL;DR: In this article, the authors identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions to ease and to expedite their deployment, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations.
Journal ArticleDOI
High‐Resolution 3D Printing for Electronics
TL;DR: The recent progress in novel 3D printing methods for freeform electronics is reviewed, with providing a comprehensive study on 3D-printable functional materials and processes for various device components.
Journal ArticleDOI
Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics
Yangzhi Zhu,Shaopei Li,Jinghang Li,Natashya Falcone,Qingyu Cui,Martin C. Hartel,Ning Yu,Patric Young,Natan Roberto de Barros,Zhuohong Wu,Reihaneh Haghniaz,Menekse Ermis,Canran Wang,Heemin Kang,Junmin Lee,Solmaz Karamikamkar,Samad Ahadian,Vadim Jucaud,Mehmet R. Dokmeci,Han-Jun Kim,Ali Khademhosseini +20 more
TL;DR: The current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed and the latest advances in diagnostic and therapeutic SCLs for clinical translation are reviewed.
Journal ArticleDOI
Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure
Qianni Wu,Junqing Liu,Jingshan Mo,Xiangling Li,Cheng Wang,Ziqi Liu,Jingbo Yang,Lelun Jiang,Weirong Chen,Hui-Jiuan Chen,Ji Wang,Xi Xie +11 more
TL;DR: In this article , an integrated wireless theranostic contact lens for in situ electrical sensing of intraocular pressure and on-demand anti-glaucoma drug delivery is presented.
Journal ArticleDOI
Smart Contact Lens with Dual‐Sensing Platform for Monitoring Intraocular Pressure and Matrix Metalloproteinase‐9
Ying Ye,Yuancai Ge,Qingwen Zhang,Meiling Yuan,Yu Cai,Kang Li,Yang Li,Ruifeng Xie,Chang-yan Xu,Danfeng Jiang,Jia Qu,Xiaohu Liu,Yi Wang +12 more
TL;DR: An optical‐based dual‐functional smart contact lens sensor has been introduced to monitor intraocular pressure (IOP) and detect matrix metalloproteinase‐9 (MMP‐9), both of which are key biomarkers in many eye‐related diseases such as glaucoma.
References
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TL;DR: The applicability of the high performance strain sensors based on the nanocomposite of silver nanowire network and PDMS elastomer in the form of the sandwich structure is demonstrated by fabricating a glove integrated with five strain sensors for the motion detection of fingers and control of an avatar in the virtual environment.
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Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin
Sheng Xu,Yihui Zhang,Yihui Zhang,Lin Jia,Kyle E. Mathewson,Kyung In Jang,Jeonghyun Kim,Jeonghyun Kim,Fu Haoran,Fu Haoran,Xian Huang,Pranav Chava,Renhan Wang,Sanat Bhole,Lizhe Wang,Yoon Joo Na,Yue Guan,Matthew T. Flavin,Zheshen Han,Yonggang Huang,John A. Rogers +20 more
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3D Printing of Free Standing Liquid Metal Microstructures
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