A specific transcription factor that can bind either the 5S RNA gene or 5S RNA.
Hugh R.B. Pelham,Donald D. Brown +1 more
TLDR
5S ribosomal RNA specifically inhibits transcription of cloned repeating units of 5S DNA in a nuclear extract of Xenopus oocytes, indicating the presence of large amounts of this protein in these cells can account for both the high rate of synthesis and the subsequent storage of5S RNA to ribosome synthesis.Abstract:
5S ribosomal RNA specifically inhibits transcription of cloned repeating units of 5S DNA in a nuclear extract of Xenopus oocytes. The inhibition can be explained by the interaction of 5S RNA with a transcription factor that binds specifically to a control region located within the 5S RNA gene. This transcription factor is identical to an abundant cytoplasmic protein that is known to be complexed with 5S RNA in immature Xenopus oocytes. Thus the presence of large amounts of this protein in these cells can account for both the high rate of synthesis and the subsequent storage of 5S RNA to ribosome synthesis.read more
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The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins
TL;DR: A 30-amino-acid segment of C/EBP, a newly discovered enhancer binding protein, shares notable sequence similarity with a segment of the cellular Myc transforming protein, and may represent a characteristic property of a new category of DNA binding proteins.
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Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes.
TL;DR: Analysis of the amino acid sequence reveals nine tandem similar units, each consisting of approximately 30 residues and containing two invariant pairs of cysteines and histidines, the most common ligands for zinc in the 7S particle of Xenopus laevis oocytes, which suggests that the protein contains repetitive zinc‐binding domains.
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A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization
Vikas P. Sukhatme,Xinmin Cao,Louise C. Chang,Chon-Hwa Tsai-Morris,Dorothy Stamenkovich,Paulo C.P. Ferreira,Donna R. Cohen,Steven A. Edwards,Thomas B. Shows,Tom Curran,Michelle M. Le Beau,Eileen D. Adamson +11 more
TL;DR: Sequence analysis of murine Egr-1 cDNA predicts a protein with three DNA binding zinc fingers, and results suggest that EGR1 may function as a transcriptional regulator in diverse biological processes.
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O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation
Stephen P. Jackson,Robert Tjian +1 more
TL;DR: It is shown that the human RNA polymerase II transcription factor Sp1 bears multiple O-linked N-acetylglucosamine (GlcNAc) monosaccharide residues, raising the possibility that O- linkage residues play a role in the mechanism or regulation of transcriptional activation of RNA polymerases II.
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Promoter sequences of eukaryotic protein-coding genes
Jeffry L. Corden,Bohdan Wasylyk,A. Buchwalder,Paolo Sassone-Corsi,Claude Kedinger,Pierre Chambon +5 more
TL;DR: Sequences which are essential for the initiation of specific transcription in vitro were shown to be located between 12 and 32 base pairs upstream from the 5' end of these genes.