A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment.
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TLDR
The BPS-O task provides a sensitive measure for observing changes in memory performance across the lifespan and may be useful for the early detection of memory impairments that may provide an early signal of later development to mild cognitive impairment.About:
This article is published in Neuropsychologia.The article was published on 2013-10-01 and is currently open access. It has received 408 citations till now. The article focuses on the topics: Recognition memory.read more
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Encoding and retrieval eye movements mediate age differences in pattern completion.
Jordana S. Wynn,Jordana S. Wynn,Bradley R. Buchsbaum,Bradley R. Buchsbaum,Jennifer D. Ryan,Jennifer D. Ryan +5 more
TL;DR: In this article, eye movement monitoring was used to quantify age-related changes in behavioral pattern completion as a function of eye movements during both encoding and partially cued retrieval, and older adults executed more gaze fixations and more similar eye movements across repeated image presentations than younger adults.
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Positive schizotypy is associated with amplified mnemonic discrimination and attenuated generalization
TL;DR: In this paper , the association between positive schizotypy, and memory alterations related to hippocampal computations in a general population sample enriched for positive schizophrenia was investigated and it was found that memory generalization is attenuated while memory specificity is elevated in participants with more pronounced positive Schizotypal traits.
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Bayesian modeling of the Mnemonic Similarity Task using multinomial processing trees
TL;DR: Stark et al. as mentioned in this paper developed new cognitive models, based on the multinomial processing tree framework, for two versions of the Mnemonic Similarity Task (MST), implemented as generative probabilistic models and applied to behavioral data using Bayesian graphical modeling methods.
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Poor Mnemonic Discrimination Predicts Overgeneralization of Fear
TL;DR: This article found that low mnemonic discrimination is associated with overgeneralization, i.e., flatter slopes of change in response to stimuli increasingly dissimilar to the conditioned stimulus.
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APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults
Molly Memel,Molly Memel,Adam M. Staffaroni,Yann Cobigo,Kaitlin B. Casaletto,Corrina Fonseca,Brianne M. Bettcher,Michael A. Yassa,Fanny M. Elahi,Amy Wolf,Howard J. Rosen,Joel H. Kramer +11 more
TL;DR: In this article, a study was designed to determine whether pattern separation was sensitive to differences in task-free hippocampal cerebral blood flow (CBF) in 130 functionally intact older adults.
References
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Mild Cognitive Impairment: Clinical Characterization and Outcome
Ronald C. Petersen,Glenn E. Smith,Stephen C. Waring,Robert J. Ivnik,Eric G. Tangalos,Emre Kokmen +5 more
TL;DR: Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions.
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A new clinical scale for the staging of dementia.
TL;DR: The Clinical Dementia Rating (CRD) was developed for a prospective study of mild senile dementia—Alzheimer type (SDAT), and was found to distinguish unambiguously among older subjects with a wide range of cognitive function.
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Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory.
TL;DR: The account presented here suggests that memories are first stored via synaptic changes in the hippocampal system, that these changes support reinstatement of recent memories in the neocortex, that neocortical synapses change a little on each reinstatement, and that remote memory is based on accumulated neocorticals changes.
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Population-based norms for the mini-mental state examination by age and educational level
TL;DR: Results presented should prove to be useful to clinicians who wish to compare an individual patient's MMSE scores with a population reference group and to researchers making plans for new studies in which cognitive status is a variable of interest.
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Trail Making Test A and B: Normative data stratified by age and education
TL;DR: The current norms represent a more comprehensive set of norms than previously available and will increase the ability of neuropsychologists to determine more precisely the degree to which scores on the TMT reflect impaired performance for varying ages and education.