A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment.
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TLDR
The BPS-O task provides a sensitive measure for observing changes in memory performance across the lifespan and may be useful for the early detection of memory impairments that may provide an early signal of later development to mild cognitive impairment.About:
This article is published in Neuropsychologia.The article was published on 2013-10-01 and is currently open access. It has received 408 citations till now. The article focuses on the topics: Recognition memory.read more
Citations
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Memory precision of object-location binding is unimpaired in APOE ε4-carriers with spatial navigation deficits
TL;DR: In this article, the authors used a continuous report paradigm in a visual memory task that required participants to recreate the spatial position of objects in a scene, and found good evidence that e3e4- carriers did not remember fewer object locations (F(1, 42)=.450, p=.506, BF01=3.12, p = 3.19).
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Within-category similarity negatively affects associative memory performance in both younger and older adults
TL;DR: This paper found that mnemonic overlap between targets and lures is detrimental to the ability to discriminate highly similar information, and that shared category membership for targets and lure events led to increased false associative memories across age groups.
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Unilateral Perforant Path Transection Does Not Alter Lateral Entorhinal Cortical or Hippocampal CA3 <i>Arc</i> Expression
Antonio Di Zazzo,R. H. Ettinger +1 more
TL;DR: In this paper , the effect of perforant path fiber loss on neuronal activity in CA3 and layer II of the lateral entorhinal cortex (LEC) in relation to mnemonic similarity task performance was evaluated.
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The graded novelty encoding task: Novelty gradually improves recognition of visual stimuli under incidental learning conditions
TL;DR: The Graded Novelty Encoding Task (GNET) as discussed by the authors was designed to generate visual stimuli by placing colored shapes in a grid, and participants were asked to differentiate between the "familiars" and novel images that varied in the degree of difference to the familiar ones.
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Artificial neural network performance based on correlation analysis qualitatively comparable with human performance in behavioral signal detection experiments.
TL;DR: It is shown that the ability to do pattern separation is crucial for high performance pattern recognition, but also for lure discrimination and depends on the proportionality between input and output network.
References
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Mild Cognitive Impairment: Clinical Characterization and Outcome
Ronald C. Petersen,Glenn E. Smith,Stephen C. Waring,Robert J. Ivnik,Eric G. Tangalos,Emre Kokmen +5 more
TL;DR: Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions.
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A new clinical scale for the staging of dementia.
TL;DR: The Clinical Dementia Rating (CRD) was developed for a prospective study of mild senile dementia—Alzheimer type (SDAT), and was found to distinguish unambiguously among older subjects with a wide range of cognitive function.
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Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory.
TL;DR: The account presented here suggests that memories are first stored via synaptic changes in the hippocampal system, that these changes support reinstatement of recent memories in the neocortex, that neocortical synapses change a little on each reinstatement, and that remote memory is based on accumulated neocorticals changes.
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Population-based norms for the mini-mental state examination by age and educational level
TL;DR: Results presented should prove to be useful to clinicians who wish to compare an individual patient's MMSE scores with a population reference group and to researchers making plans for new studies in which cognitive status is a variable of interest.
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Trail Making Test A and B: Normative data stratified by age and education
TL;DR: The current norms represent a more comprehensive set of norms than previously available and will increase the ability of neuropsychologists to determine more precisely the degree to which scores on the TMT reflect impaired performance for varying ages and education.