A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment.
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TLDR
The BPS-O task provides a sensitive measure for observing changes in memory performance across the lifespan and may be useful for the early detection of memory impairments that may provide an early signal of later development to mild cognitive impairment.About:
This article is published in Neuropsychologia.The article was published on 2013-10-01 and is currently open access. It has received 408 citations till now. The article focuses on the topics: Recognition memory.read more
Citations
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The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials
TL;DR: Recent progress in cognitive, imaging, and biomarker outcomes in the field of preclinical Alzheimer's disease, and the remaining gaps in knowledge are highlighted.
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Regulation and Function of Adult Neurogenesis: From Genes to Cognition
TL;DR: This review summarizes the recent research regarding the process of adult neurogenesis from different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit.
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Vascular hippocampal plasticity after aerobic exercise in older adults
Anne Maass,Sandra Düzel,Monique Goerke,Andreas Becke,Uwe Sobieray,Klaus Neumann,Martin Lövdén,Ulman Lindenberger,Lars Bäckman,Ruediger C. Braun-Dullaeus,Dörte Ahrens,Hans-Jochen Heinze,Notger G. Müller,Emrah Düzel +13 more
TL;DR: Aerobic exercise in young adults can induce vascular plasticity in the hippocampus, a critical region for recall and recognition memory, and whether healthy older adults also show such plasticity is investigated.
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Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance.
TL;DR: Data support a dysfunctional encoding mechanism detected by fMRI in individuals with aMCI and therapeutic intervention using fMRI to detect target engagement in response to treatment, as well as predictions based on the computational functions of the DG/CA3 elucidated in basic animal research.
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Hippocampal neurogenesis: Learning to remember.
Orly Lazarov,Carolyn Hollands +1 more
TL;DR: The cognitive assessments used for the detection of Alzheimer's disease in humans and rodent models of familial Alzheimer’s disease are discussed, and their value for unraveling the mechanism underlying the development of cognitive impairments and dementia are discussed.
References
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Reducing gist-based false recognition in older adults: encoding and retrieval manipulations.
TL;DR: Koutstaal and Schacter as discussed by the authors reported high levels of false recognition of lures that were categorically related to presented items, and older adults had higher false recognition rates than younger adults.
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High-resolution fMRI investigation of the medial temporal lobe.
TL;DR: To address the issue of cross‐participant alignment, the ROI‐LDDMM alignment technique is demonstrated to result in smaller alignment errors when compared with several other common normalization techniques, and the pattern of activation obtained in the high‐resolution functional data is similar to that obtained at lower resolution, although the spatial extent is smaller and the percent signal change is greater.
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Cognitive Aging and the Hippocampus: How Old Rats Represent New Environments
Iain A. Wilson,Sami Ikonen,Irina Gureviciene,Robert W. McMahan,Michela Gallagher,Howard Eichenbaum,Heikki Tanila +6 more
TL;DR: Recording place cells from aged and young rats as they repeatedly explored both a highly familiar environment and an initially novel environment helps to reconcile previously divergent characterizations of spatial representation in aged rats and suggest a model of cognitive aging and hippocampal function.
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Associative retrieval processes in the human medial temporal lobe: hippocampal retrieval success and CA1 mismatch detection.
TL;DR: Hippocampal subfield activation during associative retrieval and during subsequent comparisons of memory to matching or mismatching decision probes support the hypothesis that CA(1) acts as a "comparator," detecting when memory for the past and sensory input in the present diverge.
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Pattern separation deficits following damage to the hippocampus
C. Brock Kirwan,Andrew Hartshorn,Shauna M. Stark,Naomi J. Goodrich-Hunsaker,Ramona O. Hopkins,Craig E.L. Stark +5 more
TL;DR: Patients with hippocampal damage were unimpaired relative to matched controls in their baseline recognition memory, but patients were less likely to uniquely identify lures as "similar" than matched controls, indicating an impairment in pattern separation processes following damage to the hippocampus.