A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment.
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TLDR
The BPS-O task provides a sensitive measure for observing changes in memory performance across the lifespan and may be useful for the early detection of memory impairments that may provide an early signal of later development to mild cognitive impairment.About:
This article is published in Neuropsychologia.The article was published on 2013-10-01 and is currently open access. It has received 408 citations till now. The article focuses on the topics: Recognition memory.read more
Citations
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Journal ArticleDOI
Enhanced mnemonic discrimination for emotional memories: the role of arousal in interference resolution.
Ágnes Szőllősi,Mihály Racsmány +1 more
TL;DR: The findings suggest that lure discrimination is modulated by arousal and not by valence, and it is argued that noradrenergic activity might facilitate interference resolution among memory representations with similar features, and that superior pattern separation might play a key role in memory enhancement for emotional experiences.
Journal ArticleDOI
Mnemonic discrimination in treatment-seeking adults with and without PTSD.
TL;DR: Findings suggest that poor mnemonic discrimination is transdiagnostically associated with emotional disorders, and future work is merited to explore this as a measurable and potentially malleable, though non-specific, risk factor.
Posted ContentDOI
Enriching hippocampal memory function in older adults through real-world exploration
TL;DR: Following the intervention, participants’ lure discrimination index (LDI) was significantly higher than it was at baseline, while traditional recognition scores remained relatively unchanged, pointing to the viability of a spatial exploration intervention for improving hippocampally-dependent memory in older adults.
Book ChapterDOI
Pattern Separation: A Key Processing Deficit Associated with Aging?
TL;DR: This chapter reviews studies that have examined age-related changes in pattern separation in humans and rodents and discusses the potential basic science, translational, and clinical implications from these studies to illustrate the need to further examine the relationship between the brain changes associated with aging and pattern separation.
References
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Journal ArticleDOI
Mild Cognitive Impairment: Clinical Characterization and Outcome
Ronald C. Petersen,Glenn E. Smith,Stephen C. Waring,Robert J. Ivnik,Eric G. Tangalos,Emre Kokmen +5 more
TL;DR: Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions.
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A new clinical scale for the staging of dementia.
TL;DR: The Clinical Dementia Rating (CRD) was developed for a prospective study of mild senile dementia—Alzheimer type (SDAT), and was found to distinguish unambiguously among older subjects with a wide range of cognitive function.
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Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory.
TL;DR: The account presented here suggests that memories are first stored via synaptic changes in the hippocampal system, that these changes support reinstatement of recent memories in the neocortex, that neocortical synapses change a little on each reinstatement, and that remote memory is based on accumulated neocorticals changes.
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Population-based norms for the mini-mental state examination by age and educational level
TL;DR: Results presented should prove to be useful to clinicians who wish to compare an individual patient's MMSE scores with a population reference group and to researchers making plans for new studies in which cognitive status is a variable of interest.
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Trail Making Test A and B: Normative data stratified by age and education
TL;DR: The current norms represent a more comprehensive set of norms than previously available and will increase the ability of neuropsychologists to determine more precisely the degree to which scores on the TMT reflect impaired performance for varying ages and education.