ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: Executive summary and recommendations: A report of the American College of Cardiology/American Heart Association task force on practice guidelines (committee on the management of patients with unstable angina)
Eugene Braunwald,Elliott M. Antman,John W. Beasley,Robert M. Califf,Melvin D. Cheitlin,Judith S. Hochman,Robert H. Jones,Dean J. Kereiakes,Joel Kupersmith,Thomas N. Levin,Carl J. Pepine,John W. Schaeffer,Earl E. Smith,David E Steward,Pierre Theroux,Raymond J. Gibbons,Joseph S. Alpert,David P. Faxon,Valentin Fuster,Gabriel Gregoratos,Loren F. Hiratzka,Alice K. Jacobs,Sidney C. Smith +22 more
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TLDR
The present guidelines supersede the 1994 guidelines and summarize both the evidence and expert opinion and provide final recommendations for both patient evaluation and therapy.Abstract:
The American College of Cardiology (ACC)/American Heart Association (AHA) Task Force on Practice Guidelines was formed to make recommendations regarding the diagnosis and treatment of patients with known or suspected cardiovascular disease. Coronary artery disease (CAD) is the leading cause of death in the United States. Unstable angina (UA) and the closely related condition non–ST-segment elevation myocardial infarction (NSTEMI) are very common manifestations of this disease. These life-threatening disorders are a major cause of emergency medical care and hospitalizations in the United States. In 1996, the National Center for Health Statistics reported 1 433 000 hospitalizations for UA or NSTEMI. In recognition of the importance of the management of this common entity and of the rapid advances in the management of this condition, the need to revise guidelines published by the Agency for Health Care Policy and Research (AHCPR) and the National Heart, Lung and Blood Institute in 1994 was evident. This Task Force therefore formed the current committee to develop guidelines for the management of UA and NSTEMI. The present guidelines supersede the 1994 guidelines.
The customary ACC/AHA classifications I, II, and III summarize both the evidence and expert opinion and provide final recommendations for both patient evaluation and therapy:
Class I: Conditions for which there is evidence and/or general agreement that a given procedure or treatment is useful and effective .
Class II: Conditions for which there is conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of a procedure or treatment.
Class IIa: Weight of evidence/opinion is in favor of usefulness/efficacy.
Class IIb: Usefulness/efficacy is less well established by evidence/opinion.
Class III: Conditions for which there is evidence and/or general agreement that the procedure/treatment is not useful/effective and in some cases may be harmful.
The weight of the evidence was ranked highest (A) if the data …read more
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Compliance with guidelines and 1-year mortality in patients with acute myocardial infarction: a prospective study
Francois Schiele,Nicolas Meneveau,Fiona Caulfield,Renaud Fouche,Gerard Lassabe,Denis Baborier,Pierre Legalery,Jean-Pierre Bassand +7 more
TL;DR: A clear relationship between the extent of guideline implementation, and 1-year mortality was shown and this relationship remained strong after stratification on the risk score at admission and the type of MI.
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Conflicting Results Between Randomized Trials and Observational Studies on the Impact of Proton Pump Inhibitors on Cardiovascular Events When Coadministered With Dual Antiplatelet Therapy Systematic Review
Chiara Melloni,Jeffrey B. Washam,W. Schuyler Jones,Sharif Halim,Victor Hasselblad,Stephanie B. Mayer,Brooke L Heidenfelder,Rowena J. Dolor +7 more
TL;DR: In this article, the authors conducted a systematic review comparing the effectiveness and safety of concomitant use of proton pump inhibitors (PPIs) and dual antiplatelet therapy (DAPT) for cardiovascular outcomes.
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Long-term benefits of an early invasive management in acute coronary syndromes depend on intracoronary stenting and aggressive antiplatelet treatment: a metaregression.
Giuseppe Biondi-Zoccai,Antonio Abbate,Pierfrancesco Agostoni,Luca Testa,Francesco Burzotta,Marzia Lotrionte,Carlo Trani,Luigi M. Biasucci +7 more
TL;DR: The overall superiority of an early invasive approach in ACS is suggested, as long as state-of-the-art therapies are implemented.
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Prevalence of Tako-Tsubo Syndrome in a Large Urban Agglomeration
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CD40 Ligand: A Novel Target in the Fight against Cardiovascular Disease
TL;DR: The proinflammatory and procoagulant proteinCD40L represents a novel target in the treatment of atherosclerosis and ACS and a number of therapeutic agents have been shown to modulate the expression of CD40L, findings that could have important clinical applications.
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