ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: Executive summary and recommendations: A report of the American College of Cardiology/American Heart Association task force on practice guidelines (committee on the management of patients with unstable angina)
Eugene Braunwald,Elliott M. Antman,John W. Beasley,Robert M. Califf,Melvin D. Cheitlin,Judith S. Hochman,Robert H. Jones,Dean J. Kereiakes,Joel Kupersmith,Thomas N. Levin,Carl J. Pepine,John W. Schaeffer,Earl E. Smith,David E Steward,Pierre Theroux,Raymond J. Gibbons,Joseph S. Alpert,David P. Faxon,Valentin Fuster,Gabriel Gregoratos,Loren F. Hiratzka,Alice K. Jacobs,Sidney C. Smith +22 more
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The present guidelines supersede the 1994 guidelines and summarize both the evidence and expert opinion and provide final recommendations for both patient evaluation and therapy.Abstract:
The American College of Cardiology (ACC)/American Heart Association (AHA) Task Force on Practice Guidelines was formed to make recommendations regarding the diagnosis and treatment of patients with known or suspected cardiovascular disease. Coronary artery disease (CAD) is the leading cause of death in the United States. Unstable angina (UA) and the closely related condition non–ST-segment elevation myocardial infarction (NSTEMI) are very common manifestations of this disease. These life-threatening disorders are a major cause of emergency medical care and hospitalizations in the United States. In 1996, the National Center for Health Statistics reported 1 433 000 hospitalizations for UA or NSTEMI. In recognition of the importance of the management of this common entity and of the rapid advances in the management of this condition, the need to revise guidelines published by the Agency for Health Care Policy and Research (AHCPR) and the National Heart, Lung and Blood Institute in 1994 was evident. This Task Force therefore formed the current committee to develop guidelines for the management of UA and NSTEMI. The present guidelines supersede the 1994 guidelines.
The customary ACC/AHA classifications I, II, and III summarize both the evidence and expert opinion and provide final recommendations for both patient evaluation and therapy:
Class I: Conditions for which there is evidence and/or general agreement that a given procedure or treatment is useful and effective .
Class II: Conditions for which there is conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of a procedure or treatment.
Class IIa: Weight of evidence/opinion is in favor of usefulness/efficacy.
Class IIb: Usefulness/efficacy is less well established by evidence/opinion.
Class III: Conditions for which there is evidence and/or general agreement that the procedure/treatment is not useful/effective and in some cases may be harmful.
The weight of the evidence was ranked highest (A) if the data …read more
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Prognostic implications of elevated whole blood choline levels in acute coronary syndromes
Oliver Danne,Martin Möckel,Christian Lueders,Clemens Mügge,Gustav A Zschunke,Hans Lufft,Christian Müller,Ulrich Frei +7 more
TL;DR: An increased concentration of choline at hospital admission is a predictor of adverse cardiac events in patients with suspected acute coronary syndromes, and Whole blood choline may be useful for early risk stratification of these patients, particularly if troponin results are negative on admission.
Understanding Physicians' Risk Stratification of Acute Coronary Syndromes
Andrew T. Yan,Raymond T. Yan,Thao Huynh,Amparo Casanova,F. Emilio Raimondo,David Fitchett,Anatoly Langer,Shaun Goodman +7 more
TL;DR: In this article, the authors examined patient risk assessment by physicians in relation to treatment and objective risk score evaluation and the underlying patient characteristics that physicians consider to indicate high risk and found that an important treatment-risk paradox exists in the management of acute coronary syndromes (ACSs).
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Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases
TL;DR: The newly discovered roles for platelets as well as their role in hemostasis and thrombosis are covered and the promising receptor and enzymatic targets that may further decrease platelet activation are highlighted to address the myriad of pathologic conditions now known to involve platelets without significant effects on he mostasis.
Journal ArticleDOI
Bleeding complications in patients with acute coronary syndrome undergoing early invasive management can be reduced with radial access, smaller sheath sizes, and timely sheath removal
Warren J. Cantor,Kenneth W. Mahaffey,Zhen Huang,Pranab Das,Dietrich C. Gulba,Stanislav Glezer,Richard L. Gallo,John Ducas,Marc Cohen,Elliott M. Antman,Anatoly Langer,Neal S. Kleiman,Harvey D. White,Robert J. Chisholm,Robert A. Harrington,James J. Ferguson,Robert M. Califf,Shaun G. Goodman +17 more
TL;DR: Smaller sheaths, radial access, and timely sheath removal may mitigate the bleeding risk associated with potent antithrombotic/platelet therapy and early catheterization.
Journal ArticleDOI
Hypercoagulable States in Cardiovascular Disease
TL;DR: An updated review of hypercoagulable states in cardiovascular disease is provided in 3 sections: (1) inherited hyper coagULable states; (2) acquired hypercoAGulableStates; and (3) diagnosis and management.
References
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