Journal ArticleDOI
AdcAII, a new pneumococcal Zn-binding protein homologous with ABC transporters: biochemical and structural analysis.
Elodie Loisel,Lilian Jacquamet,Laurence Serre,Cédric Bauvois,Jean Luc Ferrer,Thierry Vernet,Anne Marie Di Guilmi,Claire Durmort +7 more
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TLDR
Functional and structural data provide new perspectives related to the physiological role of AdcAII in pneumococcus Zn homeostasis and a phylogenetic tree built from the sequence alignment of 68 proteins reveals a subgroup of members displaying an unusual genetic operon organisation.About:
This article is published in Journal of Molecular Biology.The article was published on 2008-09-05. It has received 113 citations till now.read more
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Coordination chemistry of bacterial metal transport and sensing.
TL;DR: Metal homeostasis is governed by the formation of specific protein-metal coordination complexes used to effect uptake, efflux, intracellular trafficking within compartments, and storage, and is the focus of this review.
Journal ArticleDOI
A Molecular Mechanism for Bacterial Susceptibility to Zinc.
Christopher A. McDevitt,Abiodun D. Ogunniyi,Eugene Valkov,Michael C. Lawrence,Bostjan Kobe,Alastair G. McEwan,James C. Paton +6 more
TL;DR: The results demonstrate that microbial susceptibility to Zn(II) toxicity is mediated by extracellular cation competition and that this can be harnessed by the innate immune response.
Journal ArticleDOI
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions
TL;DR: The roles of both types of transporters in diverse physiological processes including pathogenesis are described, points to the differences in modular assembly and depicts their common traits.
Journal ArticleDOI
Zinc uptake by Streptococcus pneumoniae depends on both AdcA and AdcAII and is essential for normal bacterial morphology and virulence.
Lucie Bayle,Suneeta Chimalapati,Guy Schoehn,Guy Schoehn,Jeremy S. Brown,Thierry Vernet,Thierry Vernet,Claire Durmort,Claire Durmort +8 more
TL;DR: The results show that AdcA and adcAII play an essential and redundant role in specifically importing zinc into the pneumococcus, and that both zinc transporters are required for proper cell division and for S. pneumoniae survival during infection.
Journal ArticleDOI
Interplay between manganese and zinc homeostasis in the human pathogen Streptococcus pneumoniae
Faith E. Jacobsen,Krystyna M. Kazmierczak,John P. Lisher,Malcolm E. Winkler,David P. Giedroc +4 more
TL;DR: It is concluded that Zn(II) toxicity results in a cytoplasmic Mn(ii) deficiency, possibly caused by competition at the Mn( II) uptake transporter protein PsaA.
References
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The CCP4 suite: programs for protein crystallography
TL;DR: The CCP4 (Collaborative Computational Project, number 4) program suite is a collection of programs and associated data and subroutine libraries which can be used for macromolecular structure determination by X-ray crystallography.
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Axel T. Brunger,Axel T. Brunger,Paul D. Adams,G M Clore,W. L. DeLano,Piet Gros,R.W. Grosse-Kunstleve,R.W. Grosse-Kunstleve,Jiansheng Jiang,J. Kuszewski,Michael Nilges,Navraj S. Pannu,Randy J. Read,Luke M. Rice,Thomas Simonson,Gregory L. Warren +15 more
TL;DR: The Crystallography & NMR System (CNS) as mentioned in this paper is a software suite for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy.
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Refinement of macromolecular structures by the maximum-likelihood method.
TL;DR: The likelihood function for macromolecular structures is extended to include prior phase information and experimental standard uncertainties and the results derived are consistently better than those obtained from least-squares refinement.
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Comparative Protein Modelling by Satisfaction of Spatial Restraints
Andrej Sali,Tom L. Blundell +1 more
TL;DR: A comparative protein modelling method designed to find the most probable structure for a sequence given its alignment with related structures, which is automated and illustrated by the modelling of trypsin from two other serine proteinases.
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ABC Transporters: From Microorganisms to Man
TL;DR: This chapter discusses thebuilding blocks of the Transmembrane Complex, and some of the properties of these blocks have changed since the publication of the original manuscript in 1993.