Journal ArticleDOI
Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey.
Edward J. Stanek,C. Sanders,K A Johansen Taber,Mona Khalid,A Patel,Robert R. Verbrugge,Barnabie C Agatep,Ronald E. Aubert,Robert S. Epstein,Felix W. Frueh +9 more
Reads0
Chats0
TLDR
An anonymous, cross‐sectional, fax‐based, national survey of US physicians' level of knowledge and extent of use of pharmacogenomic testing highlights the need for more effective physician education on the clinical value, availability, and interpretation of Pharmacogenomic tests.Abstract:
To develop a benchmark measure of US physicians' level of knowledge and extent of use of pharmacogenomic testing, we conducted an anonymous, cross-sectional, fax-based, national survey. Of 397,832 physicians receiving the survey questionnaire, 10,303 (3%) completed and returned it; the respondents were representative of the overall US physician population. The factors associated with the decision to test were evaluated using χ(2) and multivariate logistic regression. Overall, 97.6% of responding physicians agreed that genetic variations may influence drug response, but only 10.3% felt adequately informed about pharmacogenomic testing. Only 12.9% of physicians had ordered a test in the previous 6 months, and 26.4% anticipated ordering a test in the next 6 months. Early and future adopters of testing were more likely to have received training in pharmacogenomics, but only 29.0% of physicians overall had received any education in the field. Our findings highlight the need for more effective physician education on the clinical value, availability, and interpretation of pharmacogenomic tests.read more
Citations
More filters
Journal ArticleDOI
Pharmacogenomics in the clinic
Mary V. Relling,William E. Evans +1 more
TL;DR: Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving away from discovery and towards implementation of an evidenced-based strategy for improving the use of medications, thereby providing a cornerstone for precision medicine.
Journal ArticleDOI
Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC)
Kelly E. Caudle,Henry M. Dunnenberger,Robert R. Freimuth,Josh F. Peterson,Jonathan D. Burlison,Michelle Whirl-Carrillo,Stuart A. Scott,Heidi L. Rehm,Marc S. Williams,Teri E. Klein,Mary V. Relling,James M. Hoffman +11 more
TL;DR: The proposed standard terms will improve the understanding and interpretation of pharmacogenetic tests and reduce confusion by maintaining consistent nomenclature and can facilitate pharmacogenetics data sharing across diverse electronic health care record systems with clinical decision support.
Journal ArticleDOI
Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers
Henry M. Dunnenberger,Kristine R. Crews,James M. Hoffman,Kelly E. Caudle,Ulrich Broeckel,Scott C. Howard,Robert J. Hunkler,Teri E. Klein,William E. Evans,Mary V. Relling +9 more
TL;DR: Current programs that use preemptive genotyping to optimize the pharmacotherapy of patients are discussed and key processes for implementation are highlighted, including clinical decision support.
Journal ArticleDOI
Pharmacogenomics and individualized medicine: translating science into practice.
TL;DR: Key components to successful clinical implementation of pharmacogenomics will include consistent interpretation of Pharmacogenomics test results, availability of clinical guidelines for prescribing on the basis of testresults, and knowledge‐based decision support systems.
Journal ArticleDOI
Primary care physicians' knowledge of and experience with pharmacogenetic testing
TL;DR: Primary care practitioners envision a major role for themselves in the delivery of PGx testing but recognize their lack of adequate knowledge and experience about these tests, and development of effective tools for guiding PCPs in the use ofPGx tests should be a high priority.
References
More filters
Journal ArticleDOI
Inheritance and Drug Response
TL;DR: The underlying message is that inherited variations in drug effect are common and that some tests that incorporate pharmacogenetics into clinical practice are now available, with many more to follow.
Journal ArticleDOI
Genomic Medicine — An Updated Primer
TL;DR: The fundamental bases of genetic and genomic discovery are described and a new series: Genomic Medicine is launched, describing the practice of medicine is increasingly informed by genomic discovery.
Journal Article
Physician Use of Genetic Testing for Cancer Susceptibility
Louise Wideroff,Andrew N. Freedman,Lorayn Olson,Carrie N. Klabunde,William W. Davis,Kadaba P. Srinath,Robert T. Croyle,Rachel Ballard-Barbash +7 more
TL;DR: In this article, a nationally representative survey was conducted to estimate prevalence of cancer susceptibility tests (CST) use by United States physicians and assess demographic, training, practice setting, and practice patterns associated with use.
Journal Article
Physician use of genetic testing for cancer susceptibility: results of a national survey.
Louise Wideroff,Andrew N. Freedman,Lorayn Olson,Carrie N. Klabunde,William W. Davis,Kadaba P. Srinath,Robert T. Croyle,Rachel Ballard-Barbash +7 more
TL;DR: It is found that lower CST use was associated with not knowing if there were local testing and counseling facilities and the importance of establishing effective clinical approaches to test use and promoting physician education to facilitate communication with patients about cancer genetics.
Journal ArticleDOI
Pharmacogenomics education: International Society of Pharmacogenomics recommendations for medical, pharmaceutical, and health schools deans of education.
David Gurwitz,Jeantine E. Lunshof,George Dedoussis,Christodoulos S. Flordellis,Uwe Fuhr,Julia Kirchheiner,Julio Licinio,Adrián LLerena,Vangelis G. Manolopoulos,Leslie J. Sheffield,Gérard Siest,F Torricelli,Vasilis Vasiliou,S Wong +13 more
TL;DR: The participants, members of the ISP Pharmacogenomics Education Forum, proposed a document of ‘Background Statement’ and ‘Recommendations and Call for Action’ addressed to Deans of Education at Medical, Pharmaceutical, and Health Schools globally, and the result is presented here.
Related Papers (5)
CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network
Mary V. Relling,Teri E. Klein +1 more
Operational implementation of prospective genotyping for personalized medicine: The design of the Vanderbilt PREDICT project
Jill M. Pulley,Joshua C. Denny,Josh F. Peterson,Gordon R. Bernard,Cindy L. Vnencak-Jones,Andrea H. Ramirez,Jessica T. Delaney,Erica Bowton,Kevin B. Johnson,Dana C. Crawford,Jonathan S. Schildcrout,Daniel R. Masys,Holli H. Dilks,Russell A. Wilke,Ellen Wright Clayton,E. Shultz,Michael Laposata,John A. McPherson,Jim Jirjis,Dan M. Roden +19 more