Adrenal Androgens and Androgen Precursors—Definition, Synthesis, Regulation and Physiologic Actions
TLDR
The C19 steroids synthesized by the human adrenal are discussed and the features within the adrenal that allow production of these steroids are considered.Abstract:
The human adrenal produces more 19 carbon (C19) steroids, by mass, than either glucocorticoids or mineralocorticoids. However, the mechanisms regulating adrenal C19 steroid biosynthesis continue to represent one of the most intriguing mysteries of endocrine physiology. This review will discuss the C19 steroids synthesized by the human adrenal and the features within the adrenal that allow production of these steroids. Finally, we consider the effects of these steroids in normal physiology and disorders of adrenal C19 steroid excess.read more
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An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence.
Lourdes Ibáñez,Sharon E. Oberfield,Selma F. Witchel,Richard J. Auchus,R. Jeffrey Chang,Ethel Codner,Preeti Dabadghao,Feyza Darendeliler,Nancy Samir Elbarbary,Alessandra Gambineri,Cecilia Garcia Rudaz,Kathleen M. Hoeger,Abel López-Bermejo,Ken K. Ong,Alexia S Peña,Thomas Reinehr,Nicola Santoro,Manuel Tena-Sempere,Rachel H Tao,Bulent O. Yildiz,Haya Alkhayyat,Asma Deeb,Dipesalema Joel,Reiko Horikawa,Francis de Zegher,Peter A. Lee +25 more
TL;DR: This paper represents an international collaboration of paediatric endocrine and other societies aiming to improve worldwide care of adolescent girls with polycystic ovary syndrome (PCOS) under the International Consortium of Paediatric Endocrinology (ICPE).
Journal ArticleDOI
Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women.
Enrico Carmina,Didier Dewailly,Héctor F. Escobar-Morreale,Fahrettin Kelestimur,Carlos Morán,Sharon E. Oberfield,Selma F. Witchel,Ricardo Azziz +7 more
TL;DR: Evidence-based diagnostic and treatment strategies are essential for the proper management of women with NCAH, especially considering that these patients may need different therapeutic strategies at different stages during their follow-up and that appropriate genetic counseling may prevent the occurrence of CAH in their children.
Journal ArticleDOI
A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids.
TL;DR: The production and metabolism of 11-oxygenated steroids are described and their androgenic activity is discussed and highlighted to highlight the putative role of these androgens in disease states.
Journal ArticleDOI
11-Ketotestosterone Is the Dominant Circulating Bioactive Androgen During Normal and Premature Adrenarche
Juilee Rege,Adina F. Turcu,Josephine Z. Kasa-Vubu,Antonio M. Lerario,Gabriela C. Auchus,Richard J. Auchus,Joshua M. Smith,Perrin C. White,William E. Rainey +8 more
TL;DR: The findings suggest that 11KT is the dominant bioactive androgen in children during adrenarche and PremA, and its androgenic capacity suggests that it may be responsible for the phenotypic changes seen in these phenomena.
Molecular Cloning of Two Human Liver 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isoenzymes That are Identical with Chlordecone Reductase and Bile-acid Binder.
Deyashiki,Yoshihiro,Ogasawara,Akihito,Nakayama,Toshihiro,Nakanishi,Masayuki,Miyabe,Yoshiyuki,Sato,Kumiko,Hara,Akira +13 more
TL;DR: In this paper, two dihydrodiol dehydrogenases, DD2 and DD4, associated with 3 alpha-hydroxysteroid dehydrogenase activity were identified from human liver cDNA library using the antibodies.
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The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
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