Adrenergic Pharmacology and Cognition: Focus on the Prefrontal Cortex
Brian P. Ramos,Amy F.T. Arnsten +1 more
TLDR
Low levels of NE determine whether prefrontal cortical or posterior cortical systems control the authors' behavior and thought, and understanding these receptor mechanisms has led to new intelligent treatments for neuropsychiatric disorders associated with PFC dysfunction.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2007-03-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Prefrontal cortex & Working memory.read more
Citations
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The locus coeruleus and noradrenergic modulation of cognition
TL;DR: Elucidating the factors that control the activity of these neurons and the effect of noradrenaline in target regions is key to understanding how the brain allocates attention and apprehends the environment to select, store and retrieve information for generating adaptive behaviour.
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Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
Millan Mark,Yves Agid,Martin Brüne,Edward T. Bullmore,Cameron S. Carter,Nicola S. Clayton,Richard C. Connor,Sabrina Davis,Bill Deakin,Robert J. DeRubeis,Bruno Dubois,Mark A. Geyer,Guy M. Goodwin,Philip Gorwood,Thérèse M. Jay,Marian Joëls,Isabelle M. Mansuy,Andreas Meyer-Lindenberg,Declan G. Murphy,Edmund T. Rolls,Bernd Saletu,Michael Spedding,John A. Sweeney,Miles A. Whittington,Larry J. Young +24 more
TL;DR: This article critically discusses the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders, highlighting the needs to characterize the cellular and cerebral circuits underpinning cognitive function and identify more effective treatments.
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Tuning arousal with optogenetic modulation of locus coeruleus neurons.
Matthew E. Carter,Ofer Yizhar,Sachiko Chikahisa,Sachiko Chikahisa,Hieu Nguyen,Antoine Roger Adamantidis,Seiji Nishino,Karl Deisseroth,Luis de Lecea +8 more
TL;DR: It is found that there is a frequency-dependent, causal relationship among locus coeruleus firing, cortical activity, sleep-to-wake transitions and general locomotor arousal and that bursts of noradrenergic overexcitation cause behavioral attacks that resemble those seen in people with neuropsychiatric disorders.
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Orienting and Reorienting: The Locus Coeruleus Mediates Cognition through Arousal
TL;DR: Noradrenaline, released in forebrain structures, will facilitate sensory processing, enhance cognitive flexibility and executive function in the frontal cortex, and promote offline memory consolidation in limbic structures.
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School Readiness and Self-Regulation: A Developmental Psychobiological Approach
Clancy Blair,C. Cybele Raver +1 more
TL;DR: The idea that research on self-regulation powerfully highlights ways in which gaps in school readiness and later achievement are linked to poverty and social and economic inequality is illustrated and points the way to effective approaches to counteract these conditions.
References
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Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
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Cellular basis of working memory
TL;DR: The special nature of working memory was first identified in studies of human cognition, and modern neurobiological methods have identified a specific population of neurons, patterns of their intrinsic and extrinsic circuitry, and signaling molecules that are engaged in this process in animals.
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Effects of parietal injury on covert orienting of attention
TL;DR: The results show that damage to the parietal lobe produces a deficit in the disengage operation when the target is contralateral to the lesion, and suggest one mechanism of the effects of parietal lesions reported in clinical neurology.
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Principles of frontal lobe function
Donald T. Stuss,Robert T. Knight +1 more
TL;DR: The second edition of Principles of Frontal Lobe Function is a newly organized, and thoroughly updated, volume divided into 9 different sections, each co-edited by leaders in the specific domain of frontal lobe research.
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Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey.
TL;DR: Evidence is provided that dopamine plays an important role in a specific cortical function in rhesus monkeys and that this role can be pharmacologically reversed with dopamine agonists.