Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology.
Reads0
Chats0
TLDR
Aflatoxin biomarkers of internal and biologically effective doses have been integral to the establishment of the etiologic role of this toxin in human disease through better estimates of exposure, expanded knowledge of the mechanisms of disease pathogenesis, and as tools for implementing and evaluating preventive interventions.About:
This article is published in Toxicological Sciences.The article was published on 2011-03-01 and is currently open access. It has received 547 citations till now. The article focuses on the topics: Environmental exposure.read more
Citations
More filters
Journal ArticleDOI
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
TL;DR: This review describes historical milestones in the initial characterization of the KEAP1-NRF2 system and provides a comprehensive overview of the molecular mechanisms governing the functions ofKEAP1 and NRF2, as well as their roles in physiology and pathology.
Journal ArticleDOI
Mycotoxins as human carcinogens—the IARC Monographs classification
TL;DR: The present article summarizes the carcinogenic hazard assessments of those mycotoxins, especially aflatoxins (aflatoxin B1, B2, G1, G2 and M1), fumonisins (fumonisin B1 and B2) and ochratoxin A (OTA).
Journal ArticleDOI
Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management
TL;DR: This review focuses on resources, production, detection and control measures of aflatoxins to ensure food and feed safety and provides knowledge on aflatoxin toxicity to help in ensure food safety.
Journal ArticleDOI
The food metabolome: a window over dietary exposure
Augustin Scalbert,Lorraine Brennan,Claudine Manach,Cristina Andres-Lacueva,Lars O. Dragsted,John Draper,Stephen M. Rappaport,Justin J. J. van der Hooft,David S. Wishart +8 more
TL;DR: Key recommendations made during the workshop included more coordination of efforts; development of new databases, software tools, and chemical libraries for the food metabolome; and shared repositories of metabolomic data.
Journal ArticleDOI
Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics.
TL;DR: Current trends in the worldwide epidemiology, surveillance, diagnosis, standard treatments, and the emerging therapies for HCC are discussed.
References
More filters
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
Journal ArticleDOI
Global cancer statistics, 2002.
TL;DR: There are striking variations in the risk of different cancers by geographic area, most of the international variation is due to exposure to known or suspected risk factors related to lifestyle or environment, and provides a clear challenge to prevention.
Journal ArticleDOI
The environment and disease: association or causation?
TL;DR: The criteria outlined in "The Environment and Disease: Association or Causation?" help identify the causes of many diseases, including cancers of the reproductive system.
Journal Article
The environment and disease: association or causation?
TL;DR: This paper contrasts Bradford Hill’s approach with a currently fashionable framework for reasoning about statistical associations – the Common Task Framework – and suggests why following Bradford Hill, 50+ years on, is still extraordinarily reasonable.
Related Papers (5)
Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment
Yan Liu,Felicia Wu +1 more
Mycotoxins and human disease: a largely ignored global health issue
Christopher P. Wild,Yun Yun Gong +1 more
Workgroup Report: Public Health Strategies for Reducing Aflatoxin Exposure in Developing Countries
Heather Strosnider,Eduardo Azziz-Baumgartner,Marianne Bänziger,Ramesh V. Bhat,Robert E Breiman,Marie-Noel Brune,Kevin M. DeCock,Abby Dilley,John D. Groopman,K. Hell,Sara Hale Henry,Daniel P. Jeffers,Curtis M. Jolly,Pauline E. Jolly,Gilbert N. Kibata,Lauren Lewis,Xiumei Liu,George Luber,Leslie F. McCoy,Patience Mensah,Marina Miraglia,Ambrose O. Misore,Henry Njapau,Choon Nam Ong,Mary T.K. Onsongo,Samuel W. Page,Douglas L. Park,Manish Patel,Timothy D. Phillips,Maya Pineiro,Jenny Pronczuk,Helen Schurz Rogers,Carol Rubin,Myrna Sabino,Arthur W. Schaafsma,Gordon S. Shephard,Joerg Stroka,Christopher P. Wild,Jonathan T. Williams,David M. Wilson +39 more