Akt Isoforms: A Family Affair in Breast Cancer
Reads0
Chats0
TLDR
In this article, the authors analyzed current literatures on distinct functions of Akt isoforms in breast cancer and proposed an approach to target the Akt signaling pathway for cancer therapy, which is critical to effectively target this pathway.Abstract:
Akt, also known as protein kinase B (PKB), belongs to the AGC family of protein kinases. It acts downstream of the phosphatidylinositol 3-kinase (PI3K) and regulates diverse cellular processes, including cell proliferation, cell survival, metabolism, tumor growth and metastasis. The PI3K/Akt signaling pathway is frequently deregulated in breast cancer and plays an important role in the development and progression of breast cancer. There are three closely related members in the Akt family, namely Akt1(PKBα), Akt2(PKBβ) and Akt3(PKBγ). Although Akt isoforms share similar structures, they exhibit redundant, distinct as well as opposite functions. While the Akt signaling pathway is an important target for cancer therapy, an understanding of the isoform-specific function of Akt is critical to effectively target this pathway. However, our perception regarding how Akt isoforms contribute to the genesis and progression of breast cancer changes as we gain new knowledge. The purpose of this review article is to analyze current literatures on distinct functions of Akt isoforms in breast cancer.read more
Citations
More filters
Journal ArticleDOI
Beyond Proteolysis-Targeting Chimeric Molecules: Designing Heterobifunctional Molecules Based on Functional Effectors.
TL;DR: Heterobifunctional molecules other than PROTACs are introduced, the limitations of existing molecules are summarized, the main challenges are listed, and perspectives for future research directions are proposed, providing insight into alternative design strategies based on substrate-proximity-based targeting.
Journal ArticleDOI
The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions.
TL;DR: In this paper , a review of the relationship between PI3K/AKT signaling pathway and factors contributing to initiation and development of various cancers is presented, and therapeutic interventions regulating this signaling pathway have been summarized.
Journal ArticleDOI
Role of protein phosphorylation in cell signaling, disease, and the intervention therapy
Kun Pang,Wei Wang,Jia-xin Qin,Zhenjun Shi,Lin Hao,Yu‐Yang Ma,Haocheng Xu,Zhuo-Xun Wu,Deng Pan,Zhe S Chen,Cong Han +10 more
TL;DR: In this article , the authors analyzed 303 small-molecule protein phosphorylation kinase inhibitors (PKIs) registered and participated in clinical research obtained in a database named Protein Kinase Inhibitor Database (PKIDB), including 68 drugs approved by the Food and Drug Administration of the United States.
Journal ArticleDOI
AKT Serine/Threonine Kinase 2-mediated phosphorylation of Fascin Threonine 403 regulates esophageal cancer progression.
Zhi-Da Zhang,Bing Wen,Da-Jia Li,Dan Deng,Xiaodong Wu,Yinwei Cheng,Lian-Di Liao,Lin Long,Geng Dong,Lian Xu,En Min Li +10 more
TL;DR: In this article , a novel phosphorylation of Fascin Threonine 403 (Fascin-T403) mediated by AKT serine/threonine kinase 2 (AKT2) was studied using mass spectrometry data from esophageal cancer tissues (iProX database: IPX0002501000).
Journal ArticleDOI
Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches
TL;DR: Of particular interest are the data showing that miR-29b1-5p counteracts cell proliferation and migration and reduces stemness in breast tumor cells with a triple negative phenotype, and its possible implication in phenotype-specific management of breast tumors.
References
More filters
Journal ArticleDOI
Differential phosphofructokinase‑1 isoenzyme patterns associated with glycolytic efficiency in human breast cancer and paracancer tissues
TL;DR: Investigation of the glycolytic rate, regulatory enzymatic activities and the expression of phosphofructokinase-1 (PFK-1) in human breast cancer and paracancer tissues found that, depending on the pathological stage of breast cancer, theexpression of PFK-P was significantly positively correlated with the activity of PFP-1.
Journal Article
MiR-615 inhibited cell proliferation and cell cycle of human breast cancer cells by suppressing of AKT2 expression.
TL;DR: Results suggest that miR-615 represents a potential anti-onco-miR and participates in breast cancer carcinogenesis by suppressing AKT2 expression.
Journal ArticleDOI
UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway.
Yanhong Luo,Jianfeng He,Chunlin Yang,Matthew Orange,Xingcong Ren,Nick Blair,Tao Tan,Jin Ming Yang,Hua Zhu +8 more
TL;DR: It is demonstrated that UCH‐L1 promotes invasion of breast cancer cells and might serve as a potential therapeutic target for treatment of human patients with breast cancers.
Journal ArticleDOI
PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer.
Laura C. A. Galbraith,Ernest Mui,Colin Nixon,Ann Hedley,David P. Strachan,Gillian M. Mackay,David Sumpton,Owen J. Sansom,Hing Y. Leung,Imran Ahmad +9 more
TL;DR: In this article, a functional effect of PPARG on AKT serine/threonine kinase 3 (AKT3) was identified, which resulted in a more aggressive disease phenotype.
Journal ArticleDOI
Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression.
TL;DR: Akt1 may inhibit autophagy by decreasing UVRAG expression, which also sensitizes cancer cells to UV irradiation, according to a kinase activity-independent mechanism.