Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD
Mathias Haarhaus,Mathias Haarhaus,Vincent Brandenburg,Kamyar Kalantar-Zadeh,Kamyar Kalantar-Zadeh,Peter Stenvinkel,Per Magnusson +6 more
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TLDR
Novel mechanisms that link ALP to vascular calcification, inflammation, and endothelial dysfunction in kidney and cardiovascular diseases are reviewed and new drugs that target ALP are discussed, which have the potential to improve cardiovascular outcomes without inhibiting skeletal mineralization.Abstract:
Cardiovascular disease is the main cause of early death in the settings of chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), and ageing Cardiovascular events can be caused by an imbalance between promoters and inhibitors of mineralization, which leads to vascular calcification This process is akin to skeletal mineralization, which is carefully regulated and in which isozymes of alkaline phosphatase (ALP) have a crucial role Four genes encode ALP isozymes in humans Intestinal, placental and germ cell ALPs are tissue-specific, whereas the tissue-nonspecific isozyme of ALP (TNALP) is present in several tissues, including bone, liver and kidney TNALP has a pivotal role in bone calcification Experimental overexpression of TNALP in the vasculature is sufficient to induce vascular calcification, cardiac hypertrophy and premature death, mimicking the cardiovascular phenotype often found in CKD and T2DM Intestinal ALP contributes to the gut mucosal defence and intestinal and liver ALPs might contribute to the acute inflammatory response to endogenous or pathogenic stimuli Here we review novel mechanisms that link ALP to vascular calcification, inflammation, and endothelial dysfunction in kidney and cardiovascular diseases We also discuss new drugs that target ALP, which have the potential to improve cardiovascular outcomes without inhibiting skeletal mineralizationread more
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Pharmacologic epigenetic modulators of alkaline phosphatase in chronic kidney disease
Mathias Haarhaus,Dean Gilham,Ewelina Kulikowski,Per Magnusson,Kamyar Kalantar-Zadeh,Kamyar Kalantar-Zadeh,Kamyar Kalantar-Zadeh +6 more
TL;DR: Alkaline phosphatase is a predictor of CVD and mortality in CKD andEpigenetic modulation of ALP has the potential to affect several pathogenetic processes in CKd and thereby improve cardiovascular outcome.
Journal ArticleDOI
Switching On and Off Macrophages by a “Bridge-Burning” Coating Improves Bone-Implant Integration under Osteoporosis
Zhenzhen Wang,Zhenzhen Wang,Yiming Niu,Yiming Niu,Xuejiao Tian,Na Yu,Xiaoyu Yin,Zhen Xing,Yurong Li,Lei Dong,Chunming Wang +10 more
TL;DR: A bioresponsive, endogenously triggered, smart coating material is developed to sequentially harness and abolish the power of inflammation to improve osseointegration under osteoporosis, which represents a new strategy for designing immunomodulatory biomaterials for tissue regeneration.
Journal ArticleDOI
Effect of stir-frying time during Angelica Sinensis Radix processing with wine on physicochemical, structure properties and bioactivities of polysaccharides
TL;DR: In this article, a comprehensive perusal on polysaccharides from Angelica Sinensis Radix (ASPs) processing with Chinese rice wine (18, 20, 22, 24) through investigating the structural characterizations, antioxidant activity, invigorating blood circulation activity, and inhibitory activity on alkaline phosphatase.
Journal ArticleDOI
The Non-invasive Diagnosis of Bone Disorders in CKD.
TL;DR: In this article, the current role of the most often clinically used or promising biochemical circulating biomarkers such as parathyroid hormone, alkaline phosphatases, and other biochemical markers of bone activity as alternatives to some aspects of bone histomorphometry is reviewed.
Journal ArticleDOI
The PPAR-γ antagonist T007 inhibits RANKL-induced osteoclastogenesis and counteracts OVX-induced bone loss in mice.
Xiang Li,Lei Ning,Jianjun Ma,Ziang Xie,Xiangde Zhao,Gangliang Wang,Xinyu Wan,Pengcheng Qiu,Teng Yao,Haoming Wang,Shunwu Fan,Shuanglin Wan +11 more
TL;DR: It is demonstrated that T007 impedes osteoclastogenesis and will be useful for the therapy of bone related diseases, essentially osteoporosis.
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