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Alkaline phosphatase positive precursors of adipocytes in the human bone marrow.
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TLDR
Developing fat cells in the bone marrow of leukaemic patients treated with chemotherapy were found to be endowed with membrane‐bound alkaline phosphatase, providing cytochemical evidence that reticular cells may convert to adipocytes when marrow cellularity abruptly decreases.Abstract:
Developing fat cells in the bone marrow of leukaemic patients treated with chemotherapy were found to be endowed with membrane-bound alkaline phosphatase. Since alkaline phosphatase is a cytochemical marker of 'reticular' cells, this observation provides cytochemical evidence that reticular cells may convert to adipocytes when marrow cellularity abruptly decreases.read more
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Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.
TL;DR: The role and the molecular mechanism of action of regulatory molecules, such as cytokines and hormones, in osteoclast and osteoblast birth and apoptosis are reviewed to review the evidence for the contribution of changes in bone cell birth or death to the pathogenesis of the most common forms of osteoporosis.
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Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications
TL;DR: Bone marrow stromal cells are progenitors of skeletal tissue components such as bone, cartilage, the hematopoiesis‐supporting stroma, and adipocytes and represent an important paradigm of post‐natal nonhematopoietic stem cells, and an easy source for potential therapeutic use.
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Mesenchymal stem cells: Biology and potential clinical uses
TL;DR: Preclinical and early clinical safety studies are paving the way for further applications of mesenchymal stem cells in the field of transplantation with respect to hematopoietic support, immunoregulation, and graft facilitation.
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Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics
TL;DR: HMSCs isolated from adult bone marrow provide an excellent model for development of stem cell therapeutics, and their potential use in the cardiovascular system is currently under investigation in the laboratory and clinical settings.
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Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine
TL;DR: Allogeneic MSC treatments, categorized as a drug by regulatory agencies, have been widely pursued, but new studies demonstrate the efficacy of autologous MSC therapies, even for individuals affected by a disease state.
References
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Journal ArticleDOI
Conditions controlling the proliferation of haemopoietic stem cells in vitro.
TL;DR: A liquid culture system is described whereby proliferation of haemopoietic stem cells, production of granulocyte precursor cells (CFU‐C), and extensive granulopoiesis can be maintained in vitro for several months.
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The hematopoietic microenvironment of the bone marrow: An ultrastructural study of the stroma in rats
TL;DR: The stroma and vascular sinuses are described by scanning and transmission electron microscopy and in freeze‐fracture etch replicas in normal rat femoral marrow and in rats made eosinophilic by larvae of trichinella spiralis.
Journal ArticleDOI
Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors.
H Westen,D F Bainton +1 more
TL;DR: It is speculated that the alkaline-phosphatase- positive reticulum cell (Al-RC) are mesenchymal stromal cells necessary for granulocytic differentiation in bone marrow.
Journal Article
The essential cells of the hemopoietic microenvironment
T. D Allen,T. M Dexter +1 more