Journal ArticleDOI
Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction
Martin Hill,Petr Popov,Helena Havlíková,Lyudmila Kancheva,Jana Vrbikova,Radmila Kancheva,Vladimír Pouzar,Ivan Černý,Luboslav Stárka +8 more
TLDR
The reinstatement of serum estradiol, progesterone, and PI during the therapy demonstrates its favorable effect on both reproductive functions and the psychosomatic stability of the patients.About:
This article is published in Steroids.The article was published on 2005-07-01. It has received 45 citations till now. The article focuses on the topics: Progesterone secretion & Pregnenolone.read more
Citations
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Journal ArticleDOI
Sex differences and ovarian hormones in animal models of drug dependence.
TL;DR: Overall, sex and hormonal status along with other biological risk factors account for a continuum of addiction-prone and -resistant animal models that are valuable for studying drug abuse prevention and treatment strategies.
Journal ArticleDOI
A New Look at the 5α‐Reductase Inhibitor Finasteride
Deborah A. Finn,Amy S. Beadles-Bohling,Ethan H. Beckley,Matthew M. Ford,Katherine R. Gililland,Rebecca E. Gorin-Meyer,Kristine M. Wiren +6 more
TL;DR: Finasteride is the first 5α-reductase inhibitor that received clinical approval for the treatment of human benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern hair loss).
Journal Article
Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior.
TL;DR: There is evidence to support the hypothesis that neurosteroids contribute to ethanol actions and prevent excessive drinking, while the lack of neurosteroid responses to ethanol may underlie innate or chronic tolérance and increased risk of excessive drinking.
Journal ArticleDOI
The role of progestins in the behavioral effects of cocaine and other drugs of abuse: Human and animal research
TL;DR: Findings from human and animal research investigating the influence of progesterone and its metabolites allopreganolone and pregnanolone (progestins) on the effects of cocaine and other drugs of abuse suggest a possible use for these agents in understanding the etiology of and developing treatments for drug abuse.
Journal ArticleDOI
Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors.
TL;DR: Findings imply the existence of sex differences in the sensitivity of GABA(A) receptors to GABAergic steroids within circuits relevant to alcohol reward versus withdrawal, and sex Differences in the modulation of GABAergic neurosteroids may be an important consideration in understanding and developing therapeutic interventions in alcoholics.
References
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Journal ArticleDOI
Radioimmunoassay of plasma progesterone.
TL;DR: A radioimmunoassay for the measurement of plasma progesterone was described, using the 21-hemisuccinate of 11-desoxycortisol was coupled to human serum albumin using carbodiimide, and the conjugate was used to immunize 2 ewes.
Journal Article
Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.
TL;DR: Pregnenolone sulfate specifically enhances NMDA-gated currents in spinal cord neurons, while inhibiting receptors for the inhibitory amino acids glycine and gamma-aminobutyric acid, as well as non-NMDA glutamate receptors, consistent with the hypothesis that neurosteroids such as pregnenol one sulfate are involved in regulating the balance between excitation and inhibition in the central nervous system.
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Progesterone, 5α-pregnane-3,20-dione and 3α-hydroxy-5α-pregnane-20-one in specific regions of the human female brain in different endocrine states
TL;DR: In general, the study showed that there is a variation in brain concentrations depending on ovarian steroid production, indicating that the secretion pattern during the menstrual cycle is reflected in the brain.
Journal ArticleDOI
Distinct Sites for Inverse Modulation of N-Methyl-D-Aspartate Receptors by Sulfated Steroids
Mijeong Park-Chung,Fong-Sen Wu,Robert H. Purdy,Andrew Malayev,Terrell T. Gibbs,David H. Farb +5 more
TL;DR: Sulfated steroids are effective as modulators of ongoing glutamate-mediated synaptic transmission, which is consistent with their possible role as endogenous neuromodulators in the CNS.
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Estradiol and testosterone in specific regions of the human female brain in different endocrine states.
TL;DR: Findings may assist in the interpretation of functional animal studies where the hypothalamus-preoptic area and the nigrostriatal dopamine system have proved to be target areas for estradiol.