Journal ArticleDOI
Amaryllidaceae and Sceletium alkaloids
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This article is published in Natural Product Reports.The article was published on 1992-01-01. It has received 171 citations till now.read more
Citations
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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
TL;DR: This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds for complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.
Journal ArticleDOI
Asymmetric catalytic cascade reactions for constructing diverse scaffolds and complex molecules.
Yao Wang,Hong Lu,Peng-Fei Xu +2 more
TL;DR: The development of the strategy of asymmetric organocatalytic relay cascades has provided a useful tool for the controlled synthesis of specific diastereomers in complex molecules and some of these reactions are highly efficient since catalyst loadings as low as 1 mol % can promote the multistep sequences affording complex architectures with high stereoselectivities and yields.
Journal ArticleDOI
Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy
Ana Paula Murray,María Belén Faraoni,María Julia Castro,Natalia Paola Alza,Valeria Cavallaro +4 more
TL;DR: This review summarizes a total of 128 studies which correspond to the most relevant research work published during 2006-2012 (1st semester) on plant-derived compounds, plant extracts and essential oils found to elicit AChE inhibition.
Journal ArticleDOI
Synthesis of natural product inspired compound collections.
Kamal Kumar,Herbert Waldmann +1 more
TL;DR: The requirements of multistep stereoselective syntheses, and the logic and methodology of natural product total synthesis need to be translated and adapted to the methods and formats for the synthesis of compound collections.
Journal ArticleDOI
Synthesis of 1(2H)-Isoquinolones by the Nickel-Catalyzed Denitrogenative Alkyne Insertion of 1,2,3-Benzotriazin-4(3H)-ones
TL;DR: 1,2,3-Benzotriazin-4(3H)-ones reacted with internal and terminal alkynes in the presence of a nickel(0)/phosphine catalyst to give a wide range of substituted 1(2H)-isoquinolones in high yield.
References
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Journal ArticleDOI
Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile
Kittisak Likhitwitayawuid,Cindy K. Angerhofer,Heebyung Chai,John M. Pezzuto,Geoffrey A. Cordell,Nijsiri Ruangrungsi +5 more
TL;DR: A new alkaloid (-)-amabiline was isolated from the bulbs of Crinum amabile (Amaryllidaceae), and alkaloids 2, 4, and 5 were found to be the principal cytotoxic and antimalarial constituents.
Journal ArticleDOI
Stimulation of sanguinarine accumulation in Papaver somniferum cell cultures by fungal elicitors
TL;DR: Cells of a seven year old strain of Papaver somniferum L. when cultured for 2 weeks and incubated with substances known to elicit the formation of phytoalexins, responded by turning reddish brown within 6 h and accumulating sanguinarine.
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Comparative in vitro activity of sanguinarine against oral microbial isolates.
J L Dzink,S S Socransky +1 more
TL;DR: Oral reference strains and fresh isolates from human dental plaque found sanguinarine to completely inhibit the growth of 98% of the isolates at a concentration of 16 micrograms/ml.
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Construction of quaternary carbon centers by palladium-catalyzed intramolecular alkene insertions. Total synthesis of the Amaryllidaceae alkaloids (.+-.)-tazettine and (.+-.)-6a-epipretazettine
TL;DR: In this article, total synthesis of (±)-tazettine (1) and 6a-epipretazettines (3) was reported in 11 steps from the known enal 7 (14 steps from commercially available p-methoxybenzyl alcohol), with excellent yield (63-90%) and high stereo-induction (>20:1) to form 14
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Ethnobotanical drug discovery based on medicine men's trials in the African savanna: screening of East African plants for antimicrobial activity II.
Makoto Taniguchi,Isao Kubo +1 more
TL;DR: Antimicrobial activity of a number of East African plants was evaluated and plants collected based on information provided by medicine men showed a much higher probability of finding active extracts than the plants collected randomly.