Journal ArticleDOI
Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial.
Martin Adjuik,Patrice Agnamey,Abdel Babiker,Steffen Borrmann,Steffen Borrmann,Philippe Brasseur,M. Cisse,Frank Cobelens,Diallo S,Jean-François Faucher,Paul Garner,S. Gikunda,Peter G. Kremsner,Peter G. Kremsner,Sanjeev Krishna,Sanjeev Krishna,Bertrand Lell,Bertrand Lell,M. Loolpapit,Pierre-Blaise Matsiegui,Michel A. Missinou,Michel A. Missinou,J. Mwanza,Francine Ntoumi,Piero Olliaro,P. Osimbo,Philipp Rezbach,Philipp Rezbach,Eliab Some,Walter R. J. Taylor +29 more
TLDR
The combination of artesunate and amodiaquine improved treatment efficacy in Gabon and Kenya, and was equivalent in Sénégal, and is a potential combination for use in Africa.About:
This article is published in The Lancet.The article was published on 2002-04-20. It has received 307 citations till now. The article focuses on the topics: Artesunate/amodiaquine & Amodiaquine.read more
Citations
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Summary of product characteristics
Helen Andrew,Gemma Gossedge,Julie Croft,Neil Corrigan,Julia Brown,Nicholas West,Philip Quirke,Damian Tolan,Ronan A. Cahill,David Jayne +9 more
TL;DR: Trimetazidine is indicated in adults as add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled by or intolerant to first-line antianginal therapies.
Journal ArticleDOI
Antimalarial drug discovery: efficacy models for compound screening
TL;DR: Different in vitro and in vivo screens for antimalarial drug discovery are suggested and a streamlined process for evaluating new compounds on the path from drug discovery to development is recommended.
Journal ArticleDOI
Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.
TL;DR: It is provided conclusive evidence that mutant haplotypes of the pfcrt gene product of Asian, African, or South American origin confer chloroquine resistance with characteristic verapamil reversibility and reduced chlorquine accumulation.
Journal ArticleDOI
Artemisinin-based combination treatment of falciparum malaria.
TL;DR: Most malaria endemic countries have now adopted artemisinin-based combination treatments as first-line treatment of falciparum malaria, but in most of these only a minority of the patients that need artesunate-mefloquine, artemether-lumefantrine, and dihydroartemisin in-piperaquine actually receive them.
Journal ArticleDOI
Artesunate combinations for treatment of malaria: meta-analysis
TL;DR: The addition of 3 days of artesunate to standard antimalarial treatments substantially reduce treatment failure, recrudescence, and gametocyte carriage.
References
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Journal ArticleDOI
Adverse drug reactions: definitions, diagnosis, and management.
TL;DR: An adverse drug reaction is an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product.
Journal ArticleDOI
What is meant by intention to treat analysis? Survey of published randomised controlled trials
Sally Hollis,Fiona Campbell +1 more
TL;DR: Assessment of reports of randomised controlled trials published in 1997 found that intention to treat was used, but handling of deviations from randomised allocation varied widely and methods used to deal with this were generally inadequate, potentially leading to bias.
Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant
TL;DR: This work has taken an empirical approach to defining the limits of Plasmodium falciparum transmission across the continent and interpolated the distributions of projected populations in 1995 by combining a review of the literature on malaria in Africa and models of acquired functional immunity.
Journal Article
Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population.
TL;DR: In this paper, an empirical approach to define the limits of Plasmodium falciparum transmission across the continent and interpolated the distributions of projected populations in 1995 is presented.
Journal ArticleDOI
Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study
François Nosten,François Nosten,M. van Vugt,Ric N. Price,Ric N. Price,Christine Luxemburger,Christine Luxemburger,KL Thway,Alan Brockman,Alan Brockman,Rose McGready,Rose McGready,F O ter Kuile,Sornchai Looareesuwan,Nicholas J. White,Nicholas J. White +15 more
TL;DR: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and me floquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance.
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Averting a malaria disaster.
Nicholas J. White,François Nosten,Sornchai Looareesuwan,William M. Watkins,Kevin Marsh,Robert W. Snow,Gilbert Kokwaro,John H. Ouma,Tran Tinh Hien,Malcolm E. Molyneux,Malcolm E. Molyneux,Terrie E. Taylor,Terrie E. Taylor,Chris I. Newbold,TK Ruebush,M Danis,Brian Greenwood,Roy M. Anderson,Piero Olliaro +18 more