Journal ArticleDOI
Effects of artemisinin derivatives on malaria transmissibility
Ric N. Price,François Nosten,Christine Luxemburger,F O ter Kuile,Lucy Paiphun,Tan Chongsuphajaisiddhi,N J White +6 more
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TLDR
The introduction of the artemisinin derivatives in routine treatment at this study site in mid 1994 was associated with a reduction in the subsequent incidence of falciparum malaria and may prevent the spread of multidrug resistance.About:
This article is published in The Lancet.The article was published on 1996-06-15. It has received 484 citations till now. The article focuses on the topics: Gametocyte & Plasmodium falciparum.read more
Citations
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Journal ArticleDOI
Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination
Teun Bousema,Chris Drakeley +1 more
TL;DR: How control measures that aim to reduce malaria transmission, such as mass drug administration and a transmission-blocking vaccine, might better be deployed are drawn together to show how the application of molecular techniques has led to the identification of submicroscopic gametocyte carriage and to a reassessment of the human infectious reservoir.
Journal ArticleDOI
Artemisinin: mechanisms of action, resistance and toxicity.
TL;DR: At high doses, artemisinin can be neurotoxic but toxicity has not been found in clinical studies, and the mechanism of neurotoxicity may be similar to the mechanisms of action.
Journal ArticleDOI
Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar.
Achuyt Bhattarai,Abdullah S. Ali,S. Patrick Kachur,Andreas Mårtensson,Ali K Abbas,Rashid A. Khatib,Abdul-wahiyd H Al-mafazy,Mahdi Ramsan,Guida Rotllant,Jan F Gerstenmaier,Fabrizio Molteni,Salim Abdulla,Scott Montgomery,Scott Montgomery,Akira Kaneko,Anders Björkman +15 more
TL;DR: Following deployment of ACT in Zanzibar 2003, malaria-associated morbidity and mortality decreased dramatically within two years and indicated that the Millennium Development Goals of reducing mortality in children under five and alleviating the burden of malaria are achievable in tropical Africa with high coverage of combined malaria control interventions.
Journal ArticleDOI
Artemisinin-based combination treatment of falciparum malaria.
TL;DR: Most malaria endemic countries have now adopted artemisinin-based combination treatments as first-line treatment of falciparum malaria, but in most of these only a minority of the patients that need artesunate-mefloquine, artemether-lumefantrine, and dihydroartemisin in-piperaquine actually receive them.
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Artesunate combinations for treatment of malaria: meta-analysis
TL;DR: The addition of 3 days of artesunate to standard antimalarial treatments substantially reduce treatment failure, recrudescence, and gametocyte carriage.
References
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Journal ArticleDOI
Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy for malaria.
TL;DR: In this review, Nick White and Piero Olliaro discuss the rationale for combination chemotherapy and the emergence and spread of parasite resistance to commonly used antimalarial drugs.
Journal ArticleDOI
Mefloquine-resistant falciparum malaria on the Thai-Burmese border.
François Nosten,F O ter Kuile,Tan Chongsuphajaisiddhi,Christine Luxemburger,H. K. Webster,Michael D. Edstein,L Phaipun,Kyaw Lay Thew,Nicholas J. White +8 more
TL;DR: Mefloquine concentrations were no lower in those with recrudescent infections than in age-matched successfully treated patients, suggesting that pharmacokinetic factors were not responsible for the high treatment-failure rate.
Journal ArticleDOI
Evidence for cyclic development and short-lived maturity in the gametocytes of Plasmodium falciparum.
Frank Hawking,Frank Hawking,Margaret E. Wilson,Margaret E. Wilson,Kenneth Gammage,Kenneth Gammage +5 more
TL;DR: Exflagellation of the male gametocytes of Plasmodium falciparum was studied quantitatively in 4-hourly blood films taken from 5 infected children in Gambia, West Africa and it was concluded that the gametocyte probably resemble those of other periodic plasmodia in showing a (48 hour) rhythm of development to maturity.
Journal ArticleDOI
Treatment Of Multidrug-Resistant Plasmodium Falciparum Malaria With 3-Day Artesunate-Mefloquine Combination
François Nosten,François Nosten,Christine Luxemburger,Christine Luxemburger,F O ter Kuile,F O ter Kuile,Charles J. Woodrow,Charles J. Woodrow,J. Pa Eh,J. Pa Eh,Tan Chongsuphajaisiddhi,Tan Chongsuphajaisiddhi,N J White,N J White +13 more
TL;DR: Artesunate (10mg/kg over 3 days) plus mefloquine (25 mg/kg) is currently the most effective treatment for falciparum malaria in this area of increasing meFLoquine resistance.
Journal ArticleDOI
The epidemiology of malaria in a Karen population on the western border of Thailand
Christine Luxemburger,Kyaw L. Thwai,Nicholas J. White,H. K. Webster,Dennis E. Kyle,L. Maelankirri,Tan Chongsuphajaisiddhi,François Nosten +7 more
TL;DR: Findings suggest a higher transmission rate for P. vivax than P. falciparum in a Karen population on the western border of Thailand, although adults still suffered symptomatic malaria due to both species.
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