AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo.
Reads0
Chats0
TLDR
AMPK activators increase P-body formation in DRG neurons in vitro in vitro and treatment with metformin restores normal P- body numbers inDRG neurons from nerve injured mice.About:
This article is published in Neurobiology of Pain.The article was published on 2019-01-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: AMPK & Dorsal root ganglion.read more
Citations
More filters
The dynamics of mammalian P body transport, assembly, and disassembly in vivo
TL;DR: The mechanism of PB transport is revealed, and it demonstrates how PB assembly and disassembly integrate with the presence of an intact cytoskeleton, and the dynamic flux of assembled PB components was not affected by such treatments.
Journal ArticleDOI
Research Progress on Alzheimer's Disease and Resveratrol.
TL;DR: The possible relationships between AD and the following factors: synapses, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs), silent information regulator 1 (SIRT1), and estrogens are discussed.
Journal ArticleDOI
Metformin: A Prospective Alternative for the Treatment of Chronic Pain.
Guadalupe del Carmen Baeza-Flores,Crystell Guadalupe Guzmán-Priego,Leonor Ivonne Parra-Flores,Janet Murbartián,Jorge E. Torres-López,Vinicio Granados-Soto +5 more
TL;DR: The purpose of this review was to analyze the current evidence about the effects of metformin in chronic pain and three of its comorbidities (anxiety, depression and cognitive impairment).
Journal ArticleDOI
Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Patrick R. Smith,Sarah Loerch,Sarah Loerch,Nikesh Kunder,Alexander D. Stanowick,Tzu-Fang Lou,Zachary T. Campbell +6 more
TL;DR: Smith et al. as mentioned in this paper found that the eEF2K agonist nelfinavir abolishes p-bodies in sensory neurons and impairs translation, and they used cryo-electron microscopy to probe the latter.
Journal ArticleDOI
The role of stress-activated RNA-protein granules in surviving adversity.
TL;DR: In this paper, the authors discuss recent evidence for revised models of stress-activated granule functions and the role of these granules in stress survival and recovery, and suggest new roles for these structures in mRNA storage, transit, and inheritance.
References
More filters
Journal ArticleDOI
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
Nanna B. Finnerup,Nadine Attal,Simon Haroutounian,Ewan D McNicol,Ralf Baron,Robert H. Dworkin,Ian Gilron,Maija Haanpää,Per Hansson,Per Hansson,Troels S. Jensen,Troels S. Jensen,Peter R. Kamerman,Karen Lund,Andrew Moore,Srinivasa N. Raja,Andrew S.C. Rice,Andrew S.C. Rice,Michael C. Rowbotham,Emily S. Sena,Emily S. Sena,Philip J. Siddall,Philip J. Siddall,Blair H. Smith,Mark S. Wallace +24 more
TL;DR: The results support a revision of the NeuPSIG recommendations for the pharmacotherapy of neuropathic pain and allow a strong recommendation for use and proposal as first-line treatment in neuropathicPain for tricyclic antidepressants, serotonin-noradrenaline reuptake inhibitors, pregabalin, and gabapentin.
Journal ArticleDOI
Spared nerve injury : an animal model of persistent peripheral neuropathic pain
TL;DR: The spared nerve injury model differs from the Chung spinal segmental nerve, the Bennett chronic constriction injury and the Seltzer partial sciatic nerve injury models in that the co‐mingling of distal intact axons with degenerating axons is restricted, and it permits behavioral testing of the non‐injured skin territories adjacent to the denervated areas.
Journal ArticleDOI
SUnSET, a nonradioactive method to monitor protein synthesis
Enrico K. Schmidt,Giovanna Clavarino,Giovanna Clavarino,Maurizio Ceppi,Maurizio Ceppi,Philippe Pierre,Philippe Pierre +6 more
TL;DR: A nonradioactive fluorescence-activated cell sorting–based assay, called surface sensing of translation (SUnSET), which allows the monitoring and quantification of global protein synthesis in individual mammalian cells and in heterogeneous cell populations.
Journal ArticleDOI
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.
Barbara L. Cool,Bradley A. Zinker,William J. Chiou,Lemma Kifle,Ning Cao,Matthew Perham,Robert Dickinson,Andrew L. Adler,Gerard D. Gagne,Rajesh R. Iyengar,Gang Zhao,Kennan C. Marsh,Philip R. Kym,Paul M. Jung,Heidi S. Camp,Ernst U. Frevert +15 more
TL;DR: The results demonstrate that small molecule-mediated activation of AMPK in vivo is feasible and represents a promising approach for the treatment of type 2 diabetes and the metabolic syndrome.
Journal ArticleDOI
P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation
Carolyn J. Decker,Roy Parker +1 more
TL;DR: What is known about the coupling of translation and mRNA degradation, the properties of P-bodies and stress granules, and how assembly of mRNPs into larger structures might influence cellular function are reviewed.