AMPK—Sensing Energy while Talking to Other Signaling Pathways
TLDR
It is becoming clear that there is a substantial amount of crosstalk between the AMPK pathway and other signaling pathways that promote cell growth and proliferation, and this will be discussed.About:
This article is published in Cell Metabolism.The article was published on 2014-12-02 and is currently open access. It has received 472 citations till now. The article focuses on the topics: AMPK & mTORC1.read more
Citations
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Journal ArticleDOI
AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
Daniel Garcia,Reuben J. Shaw +1 more
TL;DR: The recently solved crystal structure of AMPK has shed light both into how nucleotides activate AMPK and, importantly, also into the sites bound by small molecule activators, thus providing a path for improved drugs.
Journal ArticleDOI
AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs.
TL;DR: The canonical adenine nucleotide-dependent mechanism that activates AMPK when cellular energy status is compromised, as well as other, noncanonical activation mechanisms, are reviewed.
Journal ArticleDOI
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
Lauren E. Tebay,Holly Robertson,Stephen T. Durant,Steven Vitale,Trevor M. Penning,Albena T. Dinkova-Kostova,John D. Hayes +6 more
TL;DR: Nrf2 activity is tightly controlled via CRLKeap1 and SCFβ-TrCP by oxidative stress and energy-based signals, allowing it to mediate adaptive responses that restore redox homeostasis and modulate intermediary metabolism.
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Nutrient sensing and TOR signaling in yeast and mammals
Asier González,Michael N. Hall +1 more
TL;DR: How nutrient availability is sensed and transduced to TOR in budding yeast and mammals is reviewed to allow novel strategies in the treatment for mTOR‐related diseases.
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Signaling and Function of Interleukin-2 in T Lymphocytes
Sarah H. Ross,Doreen A. Cantrell +1 more
TL;DR: It is increasingly clear that within each T cell subset, IL-2 will signal within a framework of other signal transduction networks that together will shape the transcriptional and metabolic programs that determine T cell fate.
References
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Journal ArticleDOI
TSC2 mediates cellular energy response to control cell growth and survival.
TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
TL;DR: AMP-activated protein kinase conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability.
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AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M. Gwinn,David B. Shackelford,Daniel F. Egan,Maria M. Mihaylova,Annabelle Mery,Debbie S. Vasquez,Benjamin E. Turk,Reuben J. Shaw +7 more
TL;DR: AMPK directly phosphorylates the mTOR binding partner raptor on two well-conserved serine residues, and this phosphorylation induces 14-3-3 binding to raptor, uncovering a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status.
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The role of autophagy during the early neonatal starvation period
Akiko Kuma,Masahiko Hatano,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Haruaki Nakaya,Tamotsu Yoshimori,Yoshinori Ohsumi,Takeshi Tokuhisa,Noboru Mizushima,Noboru Mizushima,Noboru Mizushima +11 more
TL;DR: The results suggest that the production of amino acids by autophagic degradation of ‘self’ proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation.