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Open AccessJournal ArticleDOI

TSC2 mediates cellular energy response to control cell growth and survival.

Ken Inoki, +2 more
- 26 Nov 2003 - 
- Vol. 115, Iss: 5, pp 577-590
TLDR
It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.
About: 
This article is published in Cell.The article was published on 2003-11-26 and is currently open access. It has received 3647 citations till now. The article focuses on the topics: AMPK & P70-S6 Kinase 1.

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Citations
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mTOR Signaling in Growth Control and Disease

Mathieu Laplante, +1 more
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI

mTOR signaling in growth control and disease.

Mathieu Laplante, +1 more
- 13 Apr 2012 - 
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI

TOR signaling in growth and metabolism.

Stephan Wullschleger, +2 more
- 10 Feb 2006 - 
TL;DR: The physiological consequences of mammalianTORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.
Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more
- 01 Feb 2011 - 
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
References
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Journal ArticleDOI

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, +13 more
- 15 Oct 2001 - 
TL;DR: It is reported that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed.
Journal ArticleDOI

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, +4 more
- 01 Sep 2002 - 
TL;DR: It is shown that TSC1–TSC2 inhibits the p70 ribosomal protein S6 kinase 1 and activates the eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translational initiation) and these functions are mediated by inhibition of the mammalian target of rapamycin (mTOR).
Journal ArticleDOI

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

Akseli Hemminki, +21 more
- 08 Jan 1998 - 
TL;DR: The molecular background of the Peutz–Jeghers syndrome, a rare hereditary disease in which there is predisposition to benign and malignant tumours of many organ systems, is investigated and truncating germline mutations in a gene residing on chromosome 19p are identified.
Journal ArticleDOI

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Simon A. Hawley, +7 more
- 24 Sep 2003 - 
TL;DR: These results provide the first description of a physiological substrate for the LKB1 tumor suppressor and suggest that it functions as an upstream regulator of AMPK.
Journal ArticleDOI

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

Brendan D. Manning, +6 more
- 01 Jul 2002 - 
TL;DR: This approach identifies the tuberous sclerosis complex-2 gene product, tuberin, as a potential target of Akt/PKB, and demonstrates that, upon activation of PI3K, tuber in is phosphorylated on consensus recognition sites forPI3K-dependent S/T kinases.
Related Papers (5)

AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Dana M. Gwinn, +7 more
- 25 Apr 2008 - 

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, +4 more
- 01 Sep 2002 - 

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more
- 01 Feb 2011 - 

TOR signaling in growth and metabolism.

Stephan Wullschleger, +2 more
- 10 Feb 2006 - 

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Do Hyung Kim, +7 more
- 26 Jul 2002 -