An international survey on the impact of COVID-19 in individuals with Down syndrome
Anke Huels,Alberto C.S. Costa,Mara Dierssen,R. Asaad Baksh,Stefania Bargagna,Nicole Bäumer,Ana Cláudia Brandão,Angelo Carfì,Maria Carmona-Iragui,Brain A Chicoine,Sujay Ghosh,Monica Lakhanpaul,Coral Manso,Miguel-Angel Mayer,Maria del Carmen Ortega,Diego Real de Asúa,Anne-Sophie Rebillat,Lauren Ashley Russell,Giuseppina Sgandurra,Diletta Valentini,Stephanie L. Sherman,Andre Strydom +21 more
TLDR
Leading signs/symptoms of COVID-19 and risk factors for severe disease course are similar to the general population, however, individuals with DS present significantly higher rates of mortality, especially from age 40.Abstract:
Background Health conditions and immune dysfunction associated with trisomy 21 (Down syndrome, DS) may impact the clinical course of COVID-19 once infected by SARS-CoV-2. Methods The T21RS COVID-19 Initiative launched an international survey for clinicians or caregivers/family members on patients with COVID-19 and DS (N=1046). De-identified survey data collected between April and October 2020 were analysed and compared with the UK ISARIC4C survey of hospitalized COVID-19 patients with and without DS. COVID-19 patients with DS from the ISARIC4C survey (ISARIC4C DS cases=100) were matched to a random set of patients without DS (ISARIC4C controls=400) and hospitalized DS cases in the T21RS survey (T21RS DS cases=100) based on age, gender, and ethnicity. Finding The mean age in the T21RS survey was 29 years (SD=18), 73% lived with their family. Similar to the general population, the most frequent signs and symptoms of COVID-19 were fever, cough, and shortness of breath. Pain and nausea were reported less frequently (p Interpretation Leading signs/symptoms of COVID-19 and risk factors for severe disease course are similar to the general population. However, individuals with DS present significantly higher rates of mortality, especially from age 40. Funding Down Syndrome Affiliates in Action, Down Syndrome Medical Interest Group-USA, GiGi’s Playhouse, Jerome Lejeune Foundation, LuMind IDSC Foundation, Matthews Foundation, National Down Syndrome Society, National Task Group on Intellectual Disabilities and Dementia Practices.read more
Citations
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The impact of COVID-19 on the social inclusion of older adults with an intellectual disability during the first wave of the pandemic in Ireland.
TL;DR: For example, during the early stages of the COVID-19 pandemic in Ireland, many older adults with ID stayed connected with family and reported rates of contact higher than were reported by others before COVID19 as mentioned in this paper.
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Transition to virtual clinic: Experience in a multidisciplinary clinic for Down syndrome.
Stephanie L. Santoro,Karen Donelan,Kelsey Haugen,Nicolas M. Oreskovic,Amy Torres,Brian G. Skotko +5 more
TL;DR: The transition from in-person office visits to virtual visits in the Down syndrome specialty program at Massachusetts General Hospital (MGH DSP) was described in this paper and reflected on the six-month experience in virtual visits.
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COVID-19 in patients with Down syndrome.
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The impact of coronavirus disease 2019 (COVID-19) on older adults with an intellectual disability during the first wave of the pandemic in Ireland
Mary McCarron,Darren McCausland,Retha Luus,Andrew P. Allen,Fintan Sheerin,Eilish Burke,Eimear McGlinchy,Fidelma Flannery,Philip McCallion +8 more
TL;DR: The data suggests that people with intellectual disability avoided the worst impacts of COVID-19 during the first infection wave in Ireland, Nevertheless, participants' health profiles suggest that this population remains at high risk for adverse infection outcomes.
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The COVID-19 pandemic should be last orders for poor care of people with neurodevelopmental disorders.
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