Journal ArticleDOI
An overview of microRNAs: Biology, functions, therapeutics, and analysis methods
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TLDR
Altered of miRNAs following exercise, their association with diseases, and therapeutic potential will be explained, and miRNA bioinformatics tools and conventional methods for miRNA detection and quantification will be discussed.Abstract:
MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and currently miRNA-mediated clinical trial has shown promising results for treatment of cancer and viral infection. This review provides an overview and update on miRNAs biogenesis, regulation of miRNAs expression, their biological functions, and role of miRNAs in epigenetics and cell-cell communication. In addition, alteration of miRNAs following exercise, their association with diseases, and therapeutic potential will be explained. Finally, miRNA bioinformatics tools and conventional methods for miRNA detection and quantification will be discussed.read more
Citations
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MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
Journal ArticleDOI
High-Fidelity and Rapid Quantification of miRNA Combining crRNA Programmability and CRISPR/Cas13a trans-Cleavage Activity.
TL;DR: The practical application ability of this CRISPR/LbuCas13a/crRNA-based signal amplification strategy was demonstrated by miRNA quantification in complex biological samples (total small RNA) and promises a great potential for early diagnosis of miRNA-related disease.
Journal ArticleDOI
MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing
Leon Tribolet,Emily Kerr,Christopher Cowled,Andrew G. D. Bean,Cameron R. Stewart,Megan Dearnley,Ryan J. Farr +6 more
TL;DR: The benefits that miRNA biomarkers offer to the diagnosis, management, and treatment of infectious diseases are outlined and new and emerging miRNA detection platforms are discussed, with a focus on rapid, point-of-care testing, to evaluate the benefits and obstacles of mi RNA biomarkers for infectious disease.
Journal ArticleDOI
Advances in multiplexed techniques for the detection and quantification of microRNAs.
TL;DR: In this article, the authors present a review of the latest developments in multiplexed approaches to miRNA detection, focusing on the demonstrated multiplexing capability and potential of each of these methods.
Journal ArticleDOI
miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis.
Feng-Jun Xiao,Dan Zhang,Ye Wu,Qinghua Jia,Lin Zhang,Yuxiang Li,Yue-Feng Yang,Hua Wang,Chu-Tse Wu,Li-Sheng Wang +9 more
TL;DR: A novel mechanism through which miR-17-92 protects endothelial cells from erastin-induced ferroptosis by targeting the A20-ACSL4 axis is revealed.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
Predicting effective microRNA target sites in mammalian mRNAs
TL;DR: It is shown that recently reported non-canonical sites do not mediate repression despite binding the miRNA, which indicates that the vast majority of functional sites are canonical.
Journal ArticleDOI
miRBase: annotating high confidence microRNAs using deep sequencing data.
Ana Kozomara,Sam Griffiths-Jones +1 more
TL;DR: An update of the miRBase database is described, including the collation and use of deep sequencing data sets to assign levels of confidence to miR base entries, and a high confidence subset of miR Base entries are provided, based on the pattern of mapped reads.
Journal ArticleDOI
Regulation of microRNA biogenesis
Minju Ha,V. Narry Kim +1 more
TL;DR: Small non-coding RNAs that function as guide molecules in RNA silencing are involved in nearly all developmental and pathological processes in animals and their dysregulation is associated with many human diseases.