Journal ArticleDOI
Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'.
TLDR
This review provides a number of recommendations that will help to define a more sound 'proof-of-concept' for antibacterial, antifungal, antiviral and antiparasitic potential in natural products.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2006-07-19. It has received 1373 citations till now. The article focuses on the topics: Antibacterial agent.read more
Citations
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Discovery and resupply of pharmacologically active plant-derived natural products: A review.
Atanas G. Atanasov,Birgit Waltenberger,Eva-Maria Pferschy-Wenzig,Thomas Linder,Christoph Wawrosch,Pavel Uhrin,Veronika Temml,Limei Wang,Stefan Schwaiger,Elke H. Heiss,Judith M. Rollinger,Judith M. Rollinger,Daniela Schuster,Johannes M. Breuss,Valery N. Bochkov,Marko D. Mihovilovic,Brigitte Kopp,Rudolf Bauer,Verena M. Dirsch,Hermann Stuppner +19 more
TL;DR: While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs in the future.
Journal ArticleDOI
Extraction, Isolation and Characterization of Bioactive Compounds from Plants' Extracts
TL;DR: The analysis of bioactive compounds present in the plant extracts involving the applications of common phytochemical screening assays, chromatographic techniques such as HPLC and, TLC as well as non-chromatographic Techniques such as immunoassay and Fourier Transform Infra Red (FTIR) are discussed.
Journal ArticleDOI
Recent advances in understanding the antibacterial properties of flavonoids
T.P. Tim Cushnie,Andrew J. Lamb +1 more
TL;DR: Flavonoids are a family of plant-derived compounds with potentially exploitable activities, including direct antibacterial activity, synergism with antibiotics, and suppression of bacterial virulence, and recent advances towards understanding these properties are described.
Journal ArticleDOI
Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases.
TL;DR: Plant extracts or phytochemicals that inhibit the growth of oral pathogens, reduce the development of biofilms and dental plaque, influence the adhesion of bacteria to surfaces and reduce the symptoms of oral diseases will be discussed further.
Journal ArticleDOI
Innovative lead discovery strategies for tropical diseases.
Solomon Nwaka,Alan Hudson +1 more
TL;DR: The different approaches to lead discovery for tropical diseases are discussed and a coordination strategy that involves highly integrated partnerships and networks between scientists in academic institutions and industry in both wealthy industrialized countries and disease-endemic countries is emphasized.
References
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Human malaria parasites in continuous culture
William Trager,James B. Jensen +1 more
TL;DR: Plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38 degrees C in RPMI 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen.
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Mechanisms of biofilm resistance to antimicrobial agents
Thien-Fah Mah,George A. O'Toole +1 more
TL;DR: Owing to the heterogeneous nature of the biofilm, it is likely that there are multiple resistance mechanisms at work within a single community.
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Docking and scoring in virtual screening for drug discovery: methods and applications.
TL;DR: Key concepts and specific features of small-molecule–protein docking methods are reviewed, selected applications are highlighted and recent advances that aim to address the acknowledged limitations of established approaches are discussed.
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Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.
TL;DR: A rapid, semiautomated microdilution method was developed for measuring the activity of potential antimalarial drugs against cultured intraerythrocytic asexual forms of the human malaria parasite Plasmodium falciparum, and results demonstrated that the method is sensitive and precise.
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A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria
TL;DR: A micro-dilution technique was developed using 96-well microplates and tetrazolium salts to indicate bacterial growth and was useful in screening plants for antimicrobial activity and for the bioassay-guided isolation of antimicrobial compounds from plants.