Journal ArticleDOI
Anti-inflammatory activity of betalain-rich dye of Beta vulgaris: effect on edema, leukocyte recruitment, superoxide anion and cytokine production
Renata M. Martinez,Daniela T. Longhi-Balbinot,Ana C. Zarpelon,Larissa Staurengo-Ferrari,Marcela M. Baracat,Sandra R. Georgetti,Roge´rio C. Sassonia,Waldiceu A. Verri,Rubia Casagrande +8 more
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TLDR
This compound presents prominent anti-inflammatory effect on carrageenan-induced paw edema and peritonitis by reducing the production of superoxide anion and the cytokines TNF-α and IL-1β, in addition to increasing IL-10 levels.Abstract:
We have recently developed betalain-rich beetroot (Beta vulgaris) dye (betalain) to be used in food products. Betalain (30-300 mg/kg) intraperitoneal (i.p.) treatment diminished carrageenan (100 µg/paw)-induced paw edema and neutrophil migration to the paw skin tissue. Betalain (100 mg/kg) treatment by subcutaneous or per oral routes also inhibited the carrageenan-induced paw edema. Importantly, the post-treatment with betalain (100 mg/kg, i.p.) significantly inhibited carrageenan- and complete Freund's adjuvant (10 µl/paw)-induced paw edema. Betalain (100 mg/kg) also reduced carrageenan (500 µg/cavity)-induced recruitment of total leukocytes, including mononuclear cells and neutrophils, as well as increasing vascular permeability in the peritoneal cavity. Furthermore, betalain significantly reduced carrageenan-induced superoxide anion, tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-1β levels in the peritoneal fluid, as well as augmenting IL-10 levels. Therefore, this compound presents prominent anti-inflammatory effect on carrageenan-induced paw edema and peritonitis by reducing the production of superoxide anion and the cytokines TNF-α and IL-1β, in addition to increasing IL-10 levels. These results suggest that betalain shows therapeutic potential that could be utilized in the treatment of inflammation-associated diseases.read more
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Journal ArticleDOI
Betalains, the nature-inspired pigments, in health and diseases
TL;DR: It seems that treatment with betalains and betalain-rich diets is not only nontoxic but could also prove to be a promising alternative to supplement therapies in oxidative stress-, inflammation-, and dyslipidemia-related diseases such as stenosis of the arteries, atherosclerosis, hypertension, and cancer, among others.
Journal ArticleDOI
Red Beetroot Betalains: Perspectives on Extraction, Processing, and Potential Health Benefits.
TL;DR: The effective extraction and processing methods of betalains from red beetroot were emphatically reviewed and a variety of recently reported bioactivities of beetroot betalain were also summarized.
Journal ArticleDOI
Stability of spray-dried beetroot extract using oligosaccharides and whey proteins.
Eloá Lourenço do Carmo,Rhana Amanda Ribeiro Teodoro,Pedro Henrique Campelo Felix,Regiane Victória de Barros Fernandes,Érica Resende Oliveira,Tais Regina Lima Abreu Veiga,Soraia Vilela Borges,Diego Alvarenga Botrel +7 more
TL;DR: In general, the simultaneous use of IN and WPI as carrier agents resulted in good stability of the beetroot extract powder, representing an opportunity for innovation in food products.
Journal ArticleDOI
Transcriptomic Analysis Reveals Key Genes Related to Betalain Biosynthesis in Pulp Coloration of Hylocereus polyrhizus.
Hua Qingzhu,Chen Chengjie,Chen Zhe,Chen Pengkun,Ma Yuewen,Wu Jingyu,Zheng Jian,Hu Guibing,Zhao Jietang,Qin YongHua +9 more
TL;DR: A preliminary betalain biosynthetic pathway for pitaya was proposed based on betalains analyses, gene expression profiles and published documents.
Journal ArticleDOI
Biological Properties and Applications of Betalains.
TL;DR: Betalains are water-soluble pigments present in vacuoles of plants of the order Caryophyllales and in mushrooms of the genera Amanita, Hygrocybe and Hygrophorus as mentioned in this paper.
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