Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure
Stephan Gielen,Volker Adams,Sven Möbius-Winkler,Axel Linke,Sandra Erbs,Jiangtao Yu,Werner Kempf,Andreas Schubert,Gerhard Schuler,Rainer Hambrecht +9 more
Reads0
Chats0
TLDR
Exercise training significantly reduced the local expression of TNF-alpha, IL-1-beta,IL-6, and iNOS in the skeletal muscle of CHF patients, suggesting that the local anti-inflammatory effects of exercise may attenuate the catabolic wasting process associated with the progression ofCHF.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2003-09-03 and is currently open access. It has received 569 citations till now. The article focuses on the topics: Skeletal muscle & Physical exercise.read more
Citations
More filters
Journal ArticleDOI
Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases
TL;DR: This review provides the reader with the up‐to‐date evidence‐based basis for prescribing exercise as medicine in the treatment of 26 different diseases: psychiatric diseases (depression, anxiety, stress, schizophrenia).
Journal ArticleDOI
Muscle as an endocrine organ: focus on muscle-derived interleukin-6.
TL;DR: This review focuses on the myokine IL-6, its regulation by exercise, its signaling pathways in skeletal muscle, and its role in metabolism in both health and disease.
Journal ArticleDOI
Clinician’s Guide to Cardiopulmonary Exercise Testing in Adults A Scientific Statement From the American Heart Association
Gary J. Balady,Ross Arena,Kathy Sietsema,Jonathan N. Myers,Lola A. Coke,Gerald F. Fletcher,Daniel E. Forman,Barry A. Franklin,Marco Guazzi,Martha Gulati,Steven J. Keteyian,Carl J. Lavie,Richard Macko,Donna Mancini,Richard V. Milani +14 more
TL;DR: CPX offers the clinician the ability to obtain a wealth of information beyond standard exercise electrocardiography testing that when appropriately applied and interpreted is underutilized by the practicing clinician.
Journal ArticleDOI
Evidence for prescribing exercise as therapy in chronic disease.
TL;DR: The evidence for prescribing exercise therapy in the treatment of metabolic syndrome‐related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases, muscle, bone and joint diseases, and cancer, depression, asthma and type 1 diabetes is presented.
Journal ArticleDOI
The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review.
TL;DR: Exercise produces a short-term, inflammatory response, whereas both cross-sectional comparisons and longitudinal exercise training studies demonstrate a long-term "anti-inflammatory" effect, which may contribute to the beneficial effects of habitual physical activity.
References
More filters
Journal ArticleDOI
Anaerobic threshold and respiratory gas exchange during exercise.
TL;DR: The I-min incremental work rate test is associated with changes in gas exchange which can be used as sensitive on-line indicators of the AT, thus bypassing the need for measuring arterial lactate or acid-base parameters to indicate anaerobiosis.
Journal ArticleDOI
Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)
Guillermo Torre-Amione,Samir R. Kapadia,Claude R. Benedict,Hakan Oral,James B. Young,Douglas L. Mann +5 more
TL;DR: Circulating levels of proinflammatory cytokines increase in patients as their functional heart failure classification deteriorates, and activation of the neurohumoral axis is unlikely to completely explain the elaboration of pro inflammatory cytokines in heart failure.
Journal ArticleDOI
Is NF-κB the sensor of oxidative stress?
Nanxin Li,Michael Karin +1 more
TL;DR: Recent studies have advanced the understanding of the signal transduction pathway leading to NF‐κB activation by cytokines and will provide insights for the mechanism by which NF-κB is regulated by oxidative stress.
Journal ArticleDOI
The expression of TNF alpha by human muscle. Relationship to insulin resistance.
TL;DR: TNF is expressed in human muscle, and is expressed at a higher level in the muscle tissue and in the cultured muscle cells from insulin resistant and diabetic subjects, which suggest another mechanism by which TNF may play an important role in human insulin resistance.
Journal ArticleDOI
Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure.
Donna M. Mancini,Glenn A. Walter,Nathaniel Reichek,Robert E. Lenkinski,Kevin K. McCully,James L. Mullen,John R. Wilson +6 more
TL;DR: Findings indicate that patients with chronic HF frequently develop significant skeletal muscle atrophy and metabolic abnormalities, which is consistent with intrinsic oxidative abnormalities.
Related Papers (5)
Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH).
Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.
Christopher M. O'Connor,David J. Whellan,David J. Whellan,Kerry L. Lee,Steven J. Keteyian,Lawton S. Cooper,Stephen J. Ellis,Eric S. Leifer,William E. Kraus,Dalane W. Kitzman,James A. Blumenthal,David S. Rendall,Nancy Houston Miller,Jerome L. Fleg,Kevin A. Schulman,Robert S. McKelvie,Faiez Zannad,Ileana L. Piña +17 more