Journal ArticleDOI
Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action.
Zoya Malik,Rabea Parveen,Bushra Parveen,Sultan Zahiruddin,Mohammad Aasif Khan,Asifa Khan,Sheersh Massey,Sayeed Ahmad,Syed Akhtar Husain +8 more
TLDR
In this article, the main emphasis was given on the anticancer activity of AG, its proposed mechanisms of action, novel approaches used to improve its biopharmaceutical properties, and its development as an adjuvant therapy for cancer treatment in future.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2021-02-18. It has received 26 citations till now. The article focuses on the topics: Andrographis paniculata & Literature survey.read more
Citations
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Journal ArticleDOI
Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application
TL;DR: Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries as discussed by the authors.
Journal ArticleDOI
Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches.
TL;DR: Wang et al. as discussed by the authors presented a comprehensive review of andrographis paniculata (Burm. f. ex Nees), including its pharmacology, pharmacokinetics, toxicity and pharmaceutical researches.
Journal ArticleDOI
Recent updates on immunological, pharmacological, and alternative approaches to combat COVID-19.
TL;DR: In this article, the authors provide an update on the efficacy and safety of the repurposed, and natural drugs to treat COVID-19 as well as the vaccines used for its prophylaxis.
Journal ArticleDOI
Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health.
TL;DR: In this article, the authors have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster, which is known for its immunostimulant activity against a variety of microbial infections thereby regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy.
Journal ArticleDOI
Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2.
Shashi Chandrama Singh,Dharmendra Kumar Khatri,Kulbhaskar Singh,Vinay Kumar Kanchupalli,Jitender Madan,Shashi Bala Singh,Harshpal Singh +6 more
TL;DR: In this paper, Andrographolide-2-hydroxypropyl-β-cyclodextrin (AND) was synthesized and characterized for antiviral and pharmacokinetic profile.
References
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Journal ArticleDOI
Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines.
TL;DR: In this paper, the anti-diabetic nephropathy effect of diterpene lactones andrographolide (AP1) and 14-deoxy-11,12-didehydroandrographology (AP2) from Andrographis paniculata was evaluated.
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Determination of andrographolide, deoxyandrographolide and neoandrographolide in the Chinese herb Andrographis paniculata by micellar electrokinetic capillary chromatography.
TL;DR: The MEKC method is demonstrated to be more appropriate for the analysis of the active compounds in A. paniculata in that it is easier and less expensive to use and does not suffer from contamination of the chromatographic column.
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Inhibition of NF-kappaB expression and allergen-induced airway inflammation in a mouse allergic asthma model by andrographolide.
TL;DR: The data indicate that Andrographolide from traditional Chinese herbal medicines could inhibit extensive infiltration of inflammatory cells in lung and decrease airway hyperreactivity.
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Preparation of andrographolide-loaded solid lipid nanoparticles and their in vitro and in vivo evaluations: characteristics, release, absorption, transports, pharmacokinetics, and antihyperlipidemic activity
TL;DR: The bioavailability and antihyperlipidemic activity of Andrographolide were improved by AND-SLNs by increasing the solubility and stability of AND in the intestine and by changing its transport mode in Caco-2 cell.
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Improved bioavailability of orally administered andrographolide from pH-sensitive nanoparticles
TL;DR: The results clearly indicate the potential of pH-sensitive nanoparticles for oral delivery of low-bioavailability phytoconstituents such as andrographolide and the improved dissolution rate owing to its reduced particle size, increased surface area and reduced diffusion layer thickness may have contributed to oral bioavailability.