Journal ArticleDOI
Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action.
Zoya Malik,Rabea Parveen,Bushra Parveen,Sultan Zahiruddin,Mohammad Aasif Khan,Asifa Khan,Sheersh Massey,Sayeed Ahmad,Syed Akhtar Husain +8 more
TLDR
In this article, the main emphasis was given on the anticancer activity of AG, its proposed mechanisms of action, novel approaches used to improve its biopharmaceutical properties, and its development as an adjuvant therapy for cancer treatment in future.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2021-02-18. It has received 26 citations till now. The article focuses on the topics: Andrographis paniculata & Literature survey.read more
Citations
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Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application
TL;DR: Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries as discussed by the authors.
Journal ArticleDOI
Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches.
TL;DR: Wang et al. as discussed by the authors presented a comprehensive review of andrographis paniculata (Burm. f. ex Nees), including its pharmacology, pharmacokinetics, toxicity and pharmaceutical researches.
Journal ArticleDOI
Recent updates on immunological, pharmacological, and alternative approaches to combat COVID-19.
TL;DR: In this article, the authors provide an update on the efficacy and safety of the repurposed, and natural drugs to treat COVID-19 as well as the vaccines used for its prophylaxis.
Journal ArticleDOI
Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health.
TL;DR: In this article, the authors have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster, which is known for its immunostimulant activity against a variety of microbial infections thereby regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy.
Journal ArticleDOI
Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2.
Shashi Chandrama Singh,Dharmendra Kumar Khatri,Kulbhaskar Singh,Vinay Kumar Kanchupalli,Jitender Madan,Shashi Bala Singh,Harshpal Singh +6 more
TL;DR: In this paper, Andrographolide-2-hydroxypropyl-β-cyclodextrin (AND) was synthesized and characterized for antiviral and pharmacokinetic profile.
References
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Journal ArticleDOI
Fabrication and in vitro/in vivo evaluation of amorphous andrographolide nanosuspensions stabilized by D-α-tocopheryl polyethylene glycol 1000 succinate/sodium lauryl sulfate
Hongzhi Qiao,Lihua Chen,Tianqi Rui,Jingxian Wang,Ting Chen,Ting-Ming Fu,Junsong Li,Liuqing Di +7 more
TL;DR: An evaluation of the anti-inflammatory effect on Carr-induced paw edema demonstrated that the ADG-NS were more effective in reducing the rate of paw swelling, producing a greater increase in the serum levels of nitric oxide and tumor necrosis factor-α.
Journal ArticleDOI
Deoxyandrographolide-19β-D-Glucoside from the Leaves of Andrographis paniculata
Chen Weiming,Liang Xiaotian +1 more
TL;DR: A new diterpene glucoside has been isolated from the leaves of Andrographis paniculata and its structure elucidated as deoxyandrographolide-19beta-D-glucoside on the basis of chemical and spectral evidence.
Journal ArticleDOI
Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-κB-dependent matrix metalloproteinase-9 expression Corrigendum in /10.3892/mmr.2019.9833
Zanjing Zhai,Xinhua Qu,Haowei Li,Zhengxiao Ouyang,Wei Yan,Guangwang Liu,Xuqiang Liu,Qiming Fan,Tingting Tang,Kerong Dai,An Qin +10 more
TL;DR: Results indicate that Andrographolide may be an effective anti-tumor agent for the treatment of breast cancer bone metastasis.
Journal ArticleDOI
Elucidating the binding interaction of andrographolide with the plasma proteins: biophysical and computational approach
TL;DR: The results provide evidence that both plasma proteins (HSA and AGP) can act as carrier proteins for ANDR, and molecular dynamics simulation revealed that the stability of the HSA–ANDR complexes reached an equilibration state at around 3000 ps, which clearly indicates the rigidity and stability of.
Journal ArticleDOI
Liposomal andrographolide dry powder inhalers for treatment of bacterial pneumonia via anti-inflammatory pathway
TL;DR: Pulmonary delivery of liposomal AG dry powder inhalers (LADPIs) for treatment of Staphylococcus aureus-induced pneumonia shows that AG regulated the immune reaction to maintain the antibacterial effect while downregulating inflammatory response so that AG showed a strong effect on bacterial pneumonia.