Journal ArticleDOI
Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action.
Zoya Malik,Rabea Parveen,Bushra Parveen,Sultan Zahiruddin,Mohammad Aasif Khan,Asifa Khan,Sheersh Massey,Sayeed Ahmad,Syed Akhtar Husain +8 more
TLDR
In this article, the main emphasis was given on the anticancer activity of AG, its proposed mechanisms of action, novel approaches used to improve its biopharmaceutical properties, and its development as an adjuvant therapy for cancer treatment in future.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2021-02-18. It has received 26 citations till now. The article focuses on the topics: Andrographis paniculata & Literature survey.read more
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Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application
TL;DR: Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries as discussed by the authors.
Journal ArticleDOI
Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches.
TL;DR: Wang et al. as discussed by the authors presented a comprehensive review of andrographis paniculata (Burm. f. ex Nees), including its pharmacology, pharmacokinetics, toxicity and pharmaceutical researches.
Journal ArticleDOI
Recent updates on immunological, pharmacological, and alternative approaches to combat COVID-19.
TL;DR: In this article, the authors provide an update on the efficacy and safety of the repurposed, and natural drugs to treat COVID-19 as well as the vaccines used for its prophylaxis.
Journal ArticleDOI
Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health.
TL;DR: In this article, the authors have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster, which is known for its immunostimulant activity against a variety of microbial infections thereby regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy.
Journal ArticleDOI
Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2.
Shashi Chandrama Singh,Dharmendra Kumar Khatri,Kulbhaskar Singh,Vinay Kumar Kanchupalli,Jitender Madan,Shashi Bala Singh,Harshpal Singh +6 more
TL;DR: In this paper, Andrographolide-2-hydroxypropyl-β-cyclodextrin (AND) was synthesized and characterized for antiviral and pharmacokinetic profile.
References
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Journal ArticleDOI
Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
Yulin Peng,Yan Wang,Ning Tang,Ning Tang,Dongdong Sun,Yu-Long Lan,Zhenlong Yu,Zhenlong Yu,Xinyu Zhao,Lei Feng,Lei Feng,Bao-Jing Zhang,Lingling Jin,Fabiao Yu,Xiaochi Ma,Xiaochi Ma,Chuanzhu Lv +16 more
TL;DR: The potential anti-cancer effects of Andro are demonstrated, indicating that Andro could inhibit COX-2 expression through attenuating p300 HAT activity and suppress angiogenesis via VEGF pathway, and thereby could be developed as an antitumor agent for the treatment of breast cancer.
Journal ArticleDOI
INCREASED TUMOR NECROSIS FACTOR ALPHA (TNF-α) AND NATURAL KILLER CELL (NK) FUNCTION USING AN INTEGRATIVE APPROACH IN LATE STAGE CANCERS
TL;DR: An aggressive combination of immunoactive Nutraceuticals was effective in significantly increasing NK function, other immune parameters and hemoglobin from PBMC or plasma in patients with late stage cancers.
Journal ArticleDOI
Anti-tumor activities of andrographolide, a diterpene from Andrographis paniculata, by inducing apoptosis and inhibiting VEGF level.
TL;DR: Andrographolide (1), a diterpenoid lactone isolated from a traditional herb, is known to possess potent anti-inflammatory activity and its inhibitory activity on the level of vascular endothelial growth factor was verified by ELISA.
Journal ArticleDOI
The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
Maik Behrens,Anne Brockhoff,Claudia Batram,Christian Kuhn,Giovanni Appendino,Wolfgang Meyerhof +5 more
TL;DR: Two natural bitter terpenoids are identified that are agonists for the orphan receptor hTAS2R50, the most distant member of the bitter taste receptors subfamily, and insights into the general breadth of tuning, functional redundancies, and relationships between pharmacological activation patterns and amino acid homologies for this receptor subfamily are presented.
Journal ArticleDOI
Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.
TL;DR: Results indicate that inhibition of cell migration by interfering with ERK1/2 and PI3K/Akt signal pathways may contribute to the anti-inflammatory activity of andrographolide.