Journal ArticleDOI
Antileishmanial drug discovery: comprehensive review of the last 10 years
Jaiprakash N. Sangshetti,Firoz A. Kalam Khan,Abhishek A. Kulkarni,Rohidas Arote,Rajendra Patil +4 more
TLDR
The developments of the last decade are reviewed, covering all aspects of leishmaniasis including clinically used drugs, various new classes of antileishmanial agents (synthetic as well as natural), patented antileISHmanialagents, and possible drug targets.Abstract:
Leishmaniasis, a group of diseases caused by hemoflagellate obligate intracellular protozoa (trypanosomatids) from the genus Leishmania, has not received the attention it deserves and has developed into a major health problem in developing countries. No effective vaccine is available against leishmaniasis, so chemotherapy is the only effective way to treat all forms of the disease. However, the drugs currently used for treatment of human cutaneous and visceral leishmaniasis are toxic, having severe adverse reactions which limit their use. Therefore, development of novel, effective, and safe antileishmanial agents, with reduced side effects, is a major priority for health researchers, and large numbers of research reports have been published on antileishmanial agents in the last 10 years. Herein, we comprehensively review the developments of the last decade, covering all aspects of leishmaniasis including clinically used drugs, various new classes of antileishmanial agents (synthetic as well as natural), patented antileishmanial agents, and possible drug targets.read more
Citations
More filters
Journal ArticleDOI
Ultrasonic treatment of CoFe2O4@B2O3-SiO2 as a new hybrid magnetic composite nanostructure and catalytic application in the synthesis of dihydroquinazolinones.
TL;DR: This novel protocol offers several advantages such as high yields, short reaction times, environmentally-friendly reaction media, easily isolation of the products, simple preparation and recoverability of the nanocatalysts, recycling of the solvents from the reaction mixture without use of hazardous volatile organic solvent.
Journal ArticleDOI
Structure based medicinal chemistry-driven strategy to design substituted dihydropyrimidines as potential antileishmanial agents.
Umer Rashid,Umer Rashid,Riffat Sultana,Nargis Shaheen,Syed Fahad Hassan,Farhana Yaqoob,Muhammad Jawad Ahmad,Fatima Iftikhar,Nighat Sultana,Saba Asghar,Masoom Yasinzai,Farzana Latif Ansari,Naveeda Akhter Qureshi +12 more
TL;DR: Experimental analysis and predicted molecular properties supported the experimental analysis that these compounds have potential to eradicate both visceral and topical leishmaniasis.
Journal ArticleDOI
Nanostructured delivery systems with improved leishmanicidal activity: a critical review.
Natascia Bruni,Barbara Stella,Leonardo Giraudo,Carlo Della Pepa,Daniela Gastaldi,Franco Dosio +5 more
TL;DR: This review discusses studies on nanocarriers that have greatly contributed to improving the efficacy of antileishmaniasis drugs, presenting a critical review and some suggestions for improving drug delivery.
Journal ArticleDOI
Antileishmanial Activity of Pyrazolopyridine Derivatives and Their Potential as an Adjunct Therapy with Miltefosine.
Devireddy Anand,Pawan Kumar Yadav,Om P. S. Patel,Naveen Parmar,Rahul K. Maurya,Preeti Vishwakarma,Kanumuri Siva Rama Raju,Isha Taneja,Muhammad Wahajuddin,Susanta Kar,Prem P. Yadav +10 more
TL;DR: Investigating the effect of 6j on Leishmania promastigotes revealed that it induced molecular events, such as a loss in mitochondrial membrane potential, externalization of phosphatidylserine, and DNA fragmentation, that ultimately resulted in the programmed cell death of the parasite.
Journal ArticleDOI
Leishmania treatment and prevention: Natural and synthesized drugs.
Adnan A. Bekhit,Adnan A. Bekhit,Eman J. El-Agroudy,Aliaa Helmy,Tamer M. Ibrahim,Amin Shavandi,Alaa El-Din A. Bekhit +6 more
TL;DR: This review focuses on recent findings in drugs used for the treatment of leishmaniasis including; chemical and natural antileishmanial moieties, different potential targets, as well as various trials of vaccination development.
References
More filters
Journal ArticleDOI
Leishmaniasis Worldwide and Global Estimates of Its Incidence
Jorge Alvar,Iván D. Vélez,Iván D. Vélez,Caryn Bern,Mercè Herrero,Philippe Desjeux,Jorge Cano,Jean Jannin,Margriet den Boer +8 more
TL;DR: Visceral and cutaneous leishmaniasis incidence ranges were estimated by country and epidemiological region based on reported incidence, underreporting rates if available, and the judgment of national and international experts.
Journal ArticleDOI
Drug Resistance in Leishmaniasis
TL;DR: It is essential that there be a strategy to prevent the emergence of resistance to new drugs; combination therapy, monitoring of therapy, and improved diagnostics could play an essential role in this strategy.
Journal ArticleDOI
Leishmaniasis– current chemotherapy and recent advances in the search for novel drugs
Simon L. Croft,Graham H. Coombs +1 more
TL;DR: The immunomodulator imiquimod has proved to be an adjunct for CL therapy and the search for new drugs continues, with bisphosphonates, for example, risedronate and pamidronate, and plant derivatives being reported to have activity against experimental animal infections.
Journal ArticleDOI
Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years.
TL;DR: A review of leishmaniasis that are of practical value to practitioners, including presentation, diagnosis, and chemotherapy, can be found in this paper, where the authors emphasize advances in chemotherapy over the last 10 years.
Journal ArticleDOI
Amphotericin B: side effects and toxicity
TL;DR: Human studies show convincingly that sodium loading in excess of the usual dietary intake notably reduces the incidence and severity of AmB-induced nephrotoxicity.