Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Effects of Azolla pinnata Ethanolic Extract against Lead-Induced Hepatotoxicity in Rats.
Ahmed Shaaban Abd Elrasoul,Ahmed Mousa,Sahar H. Orabi,Mostafa A. Mohamed,Shaban M. Gad-Allah,Rafa Almeer,Mohamed M. Abdel-Daim,Mohamed M. Abdel-Daim,Shaden A. M. Khalifa,Hesham R. El-Seedi,Hesham R. El-Seedi,Hesham R. El-Seedi,Mabrouk Attia Abd Eldaim +12 more
TLDR
The administration of APE ameliorated the lead-induced alterations in liver function and structure, exemplifying the benefits of Azolla’s phytochemical contents.Abstract:
The current study investigated the protective potential of Azolla pinnate ethanolic extract (APE) against lead-induced hepatotoxicity in rats. Sixty male Wistar albino rats were randomly allocated into six groups (n = 10). The control group was orally administrated with saline. The second group received lead acetate (100 mg/kg body weight (BW) orally for 60 days). The third group was fed with APE (10 mg/kg BW orally for 60 days). The fourth group was administrated with lead acetate like the second group and APE like the third group, concomitantly, for 60 days. The fifth group was administrated with APE like the third group for 30 days, then orally administrated with the lead acetate like the second group for another 30 days. The sixth group was administrated with lead acetate like the second group for 30 days, then with APE like the third group for a further 30 days. Phytochemical analysis of APE indicated the presence of peonidin 3-O-glucoside cation, vitexin, rutin, thiamine, choline, tamarixetin, hyperoside, astragalin, and quercetin. The latter has been elucidated using one- and two-dimensional nuclear magnetic resonance (1D and 2D NMR) and liquid chromatography-mass spectrometry (LC-MS-MS). Lead acetate increased the serum levels of alanine and aspartate aminotransferases and that of urea, creatinine, tumor necrosis factor alpha, and interleukin 1β, hepatic tissue malondialdehyde contents, and caspase 3 protein expression, as well as altering the hepatic tissue architecture. However, it decreased the serum levels of interleukin 10 and glutathione (GSH) contents, and the activities of catalase and superoxide dismutase in hepatic tissue. In contrast, the administration of APE ameliorated the lead-induced alterations in liver function and structure, exemplifying the benefits of Azolla's phytochemical contents. Collectively, A. pinnate extract is a protective and curative agent against lead-induced hepatotoxicity via its antioxidant, anti-inflammatory, and anti-apoptotic impacts.read more
Citations
More filters
Journal ArticleDOI
Preventive Effect of Limosilactobacillus fermentum SCHY34 on Lead Acetate-Induced Neurological Damage in SD Rats
TL;DR: Animal experiments showed that L. fermentum SCHY34 showed a great biological scavenging and potential effect on alleviating the toxicity of lead ions and in vitro survival rate and the lead ion adsorption rate.
Journal ArticleDOI
Advances and Applications of Water Phytoremediation: A Potential Biotechnological Approach for the Treatment of Heavy Metals from Contaminated Water.
Cristián Raziel Delgado-González,Alfredo Madariaga-Navarrete,José Miguel Fernández-Cortés,Margarita Islas-Pelcastre,Goldie Oza,Hafiz M.N. Iqbal,Ashutosh Sharma +6 more
TL;DR: In this paper, the importance of applied science and environmental engineering to generate sustainable strategies to improve water quality is discussed with suitable examples by comparing different mechanistic processes, which need to be studied from a multidisciplinary perspective to make water phytoremediation a viable method.
Journal ArticleDOI
Comparative LC–LTQ–MS–MS Analysis of the Leaf Extracts of Lantana camara and Lantana montevidensis Growing in Egypt with Insights into Their Antioxidant, Anti-Inflammatory, and Cytotoxic Activities
Mariam I. Gamal El-Din,Nouran M. Fahmy,Fulin Wu,Maha Salem,Omar M. Khattab,Hesham R. El-Seedi,Michal Korinek,Tsong-Long Hwang,Ahmed Kamal Eldin Osman,Mohamed El-Shazly,Shaimaa Fayez +10 more
TL;DR: In this paper , the in-vitro antioxidants and anti-inflammatory and anticancer activities of Lantana camara and L. montevidensis extracts were investigated.
Journal ArticleDOI
An overview on the aquatic fern Azolla spp. as a sustainable source of nutrients and bioactive compounds with resourceful applications
TL;DR: Azolla is a genus of aquatic ferns and smallleafed floating plants, native to the tropics, subtropics, and warm temperate regions of Africa, Asia, and the Americas as mentioned in this paper.
Journal ArticleDOI
Antioxidant and anti-apoptotic prophylactic effect of silymarin against lead-induced hepatorenal toxicity in rats
Mabrouk Attia Abd Eldaim,Eman Ragab Barakat,Mohamed Alkafafy,Samy Ahmed Abd Elaziz,Samy Ahmed Abd Elaziz +4 more
TL;DR: In this paper, Silymarin has been shown to have anti-apoptotic and anti-antioxidant potentials against lead-induced hepatorenal toxicity in rats.
References
More filters
Book ChapterDOI
Catalase in vitro
TL;DR: In this article, the catalytic activity of catalase has been investigated using ultraviolet (UV) spectrophotometry and Titrimetric methods, which is suitable for comparative studies for large series of measurements.
Journal ArticleDOI
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
Stanley Reitman,Sam Frankel +1 more
Journal Article
Improved method for the determination of blood glutathione.
Ernest Beutler,O Duron,B M Kelly +2 more
Journal ArticleDOI
The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen
TL;DR: The reduction of nitro blue tetrazolium (NitroBT) with NADH mediated by phenazine methosulfate (PMS) under aerobic conditions was inhibited upon addition ofsuperoxide dismutase, indicating the involvement of superoxide aninon radical in the reduction of NitroBT.
Journal ArticleDOI
Human ICE/CED-3 Protease Nomenclature
Emad S. Alnemri,David J. Livingston,Donald W. Nicholson,Guy S. Salvesen,Nancy A. Thornberry,Winnie W. Wong,Junying Yuan +6 more
TL;DR: A committee of several scientists who have been involved in the identification and characterization of these enzymes have formed a committee, with the objective of proposing a nomenclature for the human members of this protease family that is sensible and easy to use.