Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research.
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TLDR
A review of biomaterials currently used to improve cellular functions in 3D culture and the contributions of 3D cell culture to cancer research, stem cell culture and drug and toxicity screening can be found in this article.Abstract:
The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. This article reviews the biomaterials currently used to improve cellular functions in 3D culture and the contributions of 3D culture to cancer research, stem cell culture and drug and toxicity screening.read more
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Hydrogels: Properties and Applications in Biomedicine
Tzu-Chuan Ho,Chin-Chuan Chang,Hung-Pin Chan,Tze Wen Chung,Chih-Wen Shu,Kuo Pin Chuang,Tsai-Hui Duh,Min Yang,Yu-Chang Tyan +8 more
TL;DR: The basic information of hydrogels, such as structure, classification, and synthesis, are introduced and the recent applications ofHydrogels in 3D cell cultures, drug delivery, wound dressing, and tissue engineering are described.
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In Vitro 3D Cultures to Model the Tumor Microenvironment
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Bioadaptive Porous 3D Scaffolds Comprising Cellulose and Chitosan Nanofibers Constructed by Pickering Emulsion Templating
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Precision Medicine Gains Momentum: Novel 3D Models and Stem Cell-Based Approaches in Head and Neck Cancer.
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References
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A collagen‐coated sponge silk scaffold for functional meniscus regeneration
Ruijian Yan,Yangwu Chen,Yanjia Gu,Chenqi Tang,Jiayun Huang,Yejun Hu,Zefeng Zheng,Zefeng Zheng,Jisheng Ran,Boon Chin Heng,Xiao Chen,Zi Yin,Weishan Chen,Weiliang Shen,Hongwei Ouyang +14 more
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Osteogenesis of Multipotent Progenitor Cells using the Epigallocatechin Gallate-Modified Gelatin Sponge Scaffold in the Rat Congenital Cleft-Jaw Model
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