Journal ArticleDOI
Aquatic environments polluted with antibiotics and heavy metals: a human health hazard
Vinicius Vicente Martins,Maria Olívia Barboza Zanetti,André Pitondo-Silva,Eliana Guedes Stehling +3 more
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TLDR
The isolate EW32 presented a conjugative plasmid with coresistance to tetracycline and copper, reinforcing the concern that antibiotic resistance by acquisition of plasmids can be induced by the selective pressure of heavy metals in the environment.Abstract:
Aquatic environments often receive wastewater containing pollutants such as antibiotics and heavy metals from hospital sewage, as well as contaminants from soil. The presence of these pollutants can increase the rate of exchange of resistant genes between environmental and pathogenic bacteria, which can make the treatment of various types of bacterial infections in humans and animals difficult, in addition to causing environmental problems such as ecological risk. In this study, two tetracycline-resistant Pseudomonas aeruginosa (EW32 and EW33), isolated from aquatic environments close to industries and a hospital in southeastern Brazil, were investigated regarding the possible association between tetracycline and heavy metal resistance. The isolate EW32 presented a conjugative plasmid with coresistance to tetracycline and copper, reinforcing the concern that antibiotic resistance by acquisition of plasmids can be induced by the selective pressure of heavy metals in the environment.read more
Citations
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At the Nexus of Antibiotics and Metals: The Impact of Cu and Zn on Antibiotic Activity and Resistance
TL;DR: This review highlights the ways in which Cu/Zn influence antibiotic resistance development and antibiotic activity, and in so doing impact in vivo antibiotic efficacy.
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Nutrients, heavy metals and microbial communities co-driven distribution of antibiotic resistance genes in adjacent environment of mariculture.
TL;DR: Partial redundancy analysis showed that nutrients, heavy metals, and bacteria communities might directly and indirectly contribute to ARGs propagation, suggesting that the profile and dissemination of ARGs were driven by the combined effects of multiple factors in mariculture-impacted sites.
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Co-selection of antibiotic and heavy metal resistance in freshwater bacteria
TL;DR: This mini-review presents the state-of-the-art of the research on antibiotic- and HM-resistance and their connection in the environment, with a focus on HM pollution and aquatic environments.
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Association between heavy metals and antibiotic-resistant human pathogens in environmental reservoirs: A review
TL;DR: Overall, this review demonstrates heavy metals act as co-selecting agents in the proliferation of antibiotic resistance in human pathogens in multiple environmental reservoirs, and zinc and cadmium were the most commonly observed heavy metals associated with resistance to antibiotics.
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A bifunctional adsorbent with high surface area and cation exchange property for synergistic removal of tetracycline and Cu2
TL;DR: In this paper, a bifunctional adsorbent with high surface area and cation exchange character (HAR-2) was prepared via copolymerization and hydrolysis reactions for the coremoval of tetracycline and Cu 2+.
References
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Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance
Ian Chopra,Marilyn C. Roberts +1 more
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C I Kado,Shih-Tung Liu +1 more
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Sampling the Antibiotic Resistome
TL;DR: This work has shown that soil-dwelling bacteria are a reservoir of resistance determinants that can be mobilized into the microbial community, and study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms.
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The antibiotic resistome: the nexus of chemical and genetic diversity
TL;DR: Understanding the molecular diversity that underlies resistance will inform the use of these drugs and guide efforts to develop new efficacious antibiotics.