Journal ArticleDOI
Are pediatric brain tumors on the rise in the USA? Significant incidence and survival findings from the SEER database analysis
Swetal Patel,Amit Bhatnagar,Christopher Wear,Stephen Osiro,Stephen Osiro,Abigail Gabriel,David Kimball,Alana John,Alana John,Paul J. Fields,R. Shane Tubbs,Marios Loukas +11 more
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The study can conclude that contrary to previous reports indicating a plateau in the incidence rates of pediatric brain tumors since the mid-1980s, there has been an increase from 1973 to 2008.Abstract:
Central nervous system tumors are the second most common form of cancer in children between the ages of 1 and 19 years. We aimed to provide the most recent data on the incidence and survival of these tumors in the USA and to assess the literature. Frequency, rates, and survival sessions were calculated using the November 2008 submission for the US Surveillance Epidemiology and End Results Program. Data were collected and analyzed for children and adolescents aged 1 to 19 years with primary brain tumors. We found that the incidence rate of all pediatric brain tumors has been on a gradual but steady increase from 1973 to 2008 (p < 0.001). The average annual increase was 1.37 %. Our survival analysis of the individual tumors revealed that the 5-year overall survival for children diagnosed between 1974 and 1978 with medulloblastoma was 43.7 %. However, this increased to 62.8 % for children diagnosed between 1999 and 2003. A similar survival trend was also observed when all the other pediatric brain cancer histologies were collectively analyzed (p < 0.001). From our study, we can conclude that contrary to previous reports indicating a plateau in the incidence rates of pediatric brain tumors since the mid-1980s, there has been an increase from 1973 to 2008. Potential causes include environmental carcinogens, but more research is needed to investigate the factors behind this sustained rise in incidence over the years.read more
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Transferrin conjugated nontoxic carbon dots for doxorubicin delivery to target pediatric brain tumor cells
Shanghao Li,Daniel Amat,Zhili Peng,Steven Vanni,Scott Raskin,Guillermo De Angulo,Abdelhameed M. Othman,Abdelhameed M. Othman,Regina M. Graham,Roger M. Leblanc +9 more
TL;DR: In vitro results demonstrate greater uptake of the C-Dots-Trans-Dox conjugate compared to Dox alone presumably owing to the high levels of transferrin receptors on these tumor cells, and significantly more cytotoxic than Dxorubicin alone.
Journal ArticleDOI
Incidence and survival trends for medulloblastomas in the United States from 2001 to 2013
Vishesh Khanna,Rebecca L. Achey,Quinn T. Ostrom,Hunter Block-Beach,Carol Kruchko,Jill S. Barnholtz-Sloan,Peter de Blank +6 more
TL;DR: Non-significant trends in the data suggest disparities in medulloblastoma incidence and survival by race, and analysis of tumor-specific trends by demographic variables can uncover clinically informative trends in cancer burden.
Journal ArticleDOI
Health disparities and impact on outcomes in children with primary central nervous system solid tumors
Mary T. Austin,Emma C. Hamilton,Denna Zebda,Hoang Nguyen,Jan M. Eberth,Yuchia Chang,Linda S. Elting,David I. Sandberg,David I. Sandberg +8 more
TL;DR: Racial/ethnic disparities are associated with advanced-stage disease presentation for children with primary CNS solid tumors and disease stage at presentation and tumor behavior are the most important predictors of survival.
Journal ArticleDOI
Traffic-related air pollution and the incidence of childhood central nervous system tumors: Texas, 2001-2009
Heather E. Danysh,Heather E. Danysh,Laura E. Mitchell,Kai Zhang,Michael E. Scheurer,Philip J. Lupo +5 more
TL;DR: A population‐based study evaluates the association between traffic‐related hazardous air pollutants (1,3‐butadiene, benzene, diesel particulate matter [DPM] and the incidence of childhood central nervous system (CNS) tumors.
Journal ArticleDOI
MiR-34a deficiency accelerates medulloblastoma formation in vivo.
Theresa Thor,Theresa Thor,A Künkele,Kristian W. Pajtler,Annika K. Wefers,Harald Stephan,Pieter Mestdagh,Lukas C. Heukamp,Wolfgang Hartmann,Jo Vandesompele,Natalie Sadowski,Lore Becker,Lillian Garrett,Sabine M. Hölter,Marion Horsch,Julia Calzada-Wack,Tanja Klein-Rodewald,Ildiko Racz,Andreas Zimmer,Johannes Beckers,Frauke Neff,Thomas Klopstock,Pasqualino De Antonellis,Massimo Zollo,Wolfgang Wurst,Helmut Fuchs,Valerie Gailus-Durner,Ulrich Schüller,Martin Hrabě de Angelis,Angelika Eggert,Alexander Schramm,Johannes H. Schulte +31 more
TL;DR: It is demonstrated that miR‐34a is dispensable for normal development, but that its loss accelerates medulloblastomagenesis and strategies aiming to re‐express miR-34a in tumors could, therefore, represent an efficient therapeutic option.
References
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Germline TP53 mutations and Li-Fraumeni syndrome.
TL;DR: The spectrum of mutations and the methods for mutation detection, the tumors associated with inheritance of a germline mutation, and some of the ethical and clinical problems in patients with a germ line TP53 mutation are discussed.
Journal ArticleDOI
Cancer surveillance series [corrected]: brain and other central nervous system cancers: recent trends in incidence and mortality.
Julie M. Legler,Lynn A. G. Ries,Malcolm A. Smith,Joan L. Warren,Heineman Ef,Richard Kaplan,Martha S. Linet +6 more
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Cancer Surveillance Series: Recent Trends in Childhood Cancer Incidence and Mortality in the United States
TL;DR: There was no substantial change in incidence for the major pediatric cancers, and rates have remained relatively stable since the mid-1980s, and Mortality rates declined steadily for all major childhood cancer categories, although less rapidly for brain/CNS cancers.
Journal ArticleDOI
Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001
TL;DR: The incidence rate of brain cancer in the US is gradually declining, but the rising trend of GBM combined with its poor survival rate is disconcerting and needs further exploration.
Journal ArticleDOI
Trends in Reported Incidence of Primary Malignant Brain Tumors in Children in the United States
TL;DR: The significantly better fit of the data to a jump model supports the hypothesis that the observed increase in incidence somehow resulted from changes in detection and/or reporting of childhood primary malignant brain tumors during the mid-1980s.
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