Arsenic metabolites; selenium; and AS3MT, MTHFR, AQP4, AQP9, SELENOP, INMT, and MT2A polymorphisms in Croatian-Slovenian population from PHIME-CROME study.
Anja Stajnko,Zdenka Šlejkovec,Darja Mazej,Alenka France-Štiglic,Alenka Sešek Briški,Igor Prpić,Zdravko Špirić,Milena Horvat,Ingrid Falnoga +8 more
TLDR
SNPs' influence on As methylation, defined particularly by the secondary methylation index (SMI), confirmed the ‘protective’ role of minor alleles of six AS3MT SNPs and their haplotype only among non‐pregnant women.About:
This article is published in Environmental Research.The article was published on 2019-03-01 and is currently open access. It has received 23 citations till now. The article focuses on the topics: Population.read more
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Results of the first national human biomonitoring in Slovenia: Trace elements in men and lactating women, predictors of exposure and reference values.
Janja Snoj Tratnik,Ingrid Falnoga,Darja Mazej,David Kocman,Vesna Fajon,Marta Jagodic,Anja Stajnko,Ajda Trdin,Zdenka Šlejkovec,Zvonka Jeran,Joško Osredkar,Alenka Sešek-Briški,Mladen Krsnik,Alfred B. Kobal,Lijana Kononenko,Milena Horvat +15 more
TL;DR: Extensive sample size database accompanied with life-style and environmental data improved the prediction of exposure patterns, set the reference values for the childbearing population living in Slovenia, and provided a strong basis for evaluating spatial and temporal trends in exposure.
Journal ArticleDOI
Mother/child organophosphate and pyrethroid distributions
Natalia Bravo,Joan O. Grimalt,Darja Mazej,Janja Snoj Tratnik,Dimosthenis Sarigiannis,Milena Horvat +5 more
TL;DR: Comparison of the estimated daily intakes with the acceptable daily intakes of all detected metabolites revealed no significant risk of adverse health effects from exposure to these pesticides.
Journal ArticleDOI
Urinary arsenic species and methylation efficiency during pregnancy: Concentrations and associated factors in Spanish pregnant women.
Raquel Soler-Blasco,Mario Murcia,Manuel Lozano,Blanca Sarzo,Ana Esplugues,Jesús Vioque,Nerea Lertxundi,Loreto Santa Marina,Aitana Lertxundi,Amaia Irizar,Simone Braeuer,Walter Goesler,Ferran Ballester,Sabrina Llop +13 more
TL;DR: In this paper, the authors describe the urinary concentrations of different As species and evaluate the methylation efficiency during pregnancy, as well as their associated factors in a birth cohort of pregnant Spanish women.
Journal ArticleDOI
Understanding the mechanistic insight of arsenic exposure and decoding the histone cipher.
TL;DR: Future prospective multi-target analyses of the inter-molecular crosstalk among different histone marks are needed to be explored further in order to understand the mechanism of arsenic toxicity and carcinogenicity and to confirm the suitability of these epi-marks as prognostic markers.
Journal ArticleDOI
Influence of AS3MT polymorphisms on arsenic metabolism and liver injury in APL patients treated with arsenic trioxide
Jing Lu,Kaijiang Yu,Shengjin Fan,Wensheng Liu,Zengxiang Dong,Jing Li,Xinyu Wang,Xin Hai,Jin Zhou +8 more
TL;DR: The data promotes the realization that AS3MT 35587 (rs11191453), 35991 (rs10748835), especially their joint genotypes 3599 1 (rs 10748835) AA / 35587 [MMA+DMA] / TC+CC, is a novel predictive biomarker for the therapeutic efficacy of As2O3 in the treatment of APL.
References
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Aquaporins in the Kidney: From Molecules to Medicine
TL;DR: In conditions with water retention such as severe congestive heart failure, pregnancy, and syndrome of inappropriate antidiuretic hormone secretion, both AQP 2 expression levels and apical plasma membrane targetting are increased, suggesting a role for AQP2 in the development of water retention.
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TL;DR: In this review, attention is paid to metallothioneins as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses, which plays a key role in regulation of zinc levels and distribution in the intracellular space.
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SELENOPROTEIN P: An Extracellular Protein with Unique Physical Characteristics and a Role in Selenium Homeostasis
Raymond F. Burk,Kristina E. Hill +1 more
TL;DR: Selenoprotein P binds to endothelial cells in the rat, and plasma levels of the protein correlate with prevention of diquat-induced lipid peroxidation and hepatic endothelial cell injury, indicating that plasma selenop protein P is the better index of human selenium nutritional status.