Arsenite Interacts Selectively with Zinc Finger Proteins Containing C3H1 or C4 Motifs
Reads0
Chats0
TLDR
It is reported that arsenite binds to both CCHC DNA-binding zinc fingers of the DNA repair protein PARP-1 (poly(ADP-ribose) polymerase-1) and that arsenITE interacts selectively with zinc finger motifs containing three or more cysteine residues.About:
This article is published in Journal of Biological Chemistry.The article was published on 2011-07-01 and is currently open access. It has received 163 citations till now. The article focuses on the topics: Zinc finger & Zinc finger nuclease.read more
Citations
More filters
Journal ArticleDOI
EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
Andrea C. Gore,Vesna A. Chappell,Suzanne E. Fenton,Jodi A. Flaws,Angel Nadal,Gail S. Prins,Jorma Toppari,R. T. Zoeller +7 more
TL;DR: A much more complete understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability, can be much better translated to human health.
Journal ArticleDOI
Arsenic toxicity: The effects on plant metabolism
Patrick M. Finnegan,Weihua Chen +1 more
TL;DR: The two forms of inorganic arsenic, arsenate (AsV) and arsenite (AsIII), are easily taken up by the cells of the plant root Once in the cell, AsV can be readily converted to AsIII, the more toxic of the two forms AsV and AsIII both disrupt plant metabolism, but through distinct mechanisms as mentioned in this paper.
Journal ArticleDOI
Arsenic binding to proteins.
TL;DR: Although the adverse health effects arising from exposure to arsenic have been well-recognized, the mechanism(s) of action responsible for the diverse range of health effects are complicated and poorly understood.
Journal ArticleDOI
Arsenic contamination of groundwater: a review of sources, prevalence, health risks, and strategies for mitigation.
Shiv Shankar,Uma Shanker,Shikha +2 more
TL;DR: The paper provides an overview of the state-of-the-art knowledge on the alternative As free drinking water and various technologies (oxidation, coagulation flocculation, adsorption, and microbial) for mitigation of the problem of As contamination of groundwater.
Journal ArticleDOI
The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review
TL;DR: This review will focus on the current epidemiological evidence of arsenic neurotoxicity in children and adults, with emphasis on cognitive dysfunction, including learning and memory deficits and mood disorders, and new studies focusing on therapeutic strategies to combat arsenic toxicity including the use of selenium and zinc.
References
More filters
Journal ArticleDOI
Poly(ADP-ribose): novel functions for an old molecule.
TL;DR: The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD+, is a unique post-translational modification that regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated.
Journal ArticleDOI
PARP inhibition: PARP1 and beyond
TL;DR: What is known about the structures and functions of the family ofPARP enzymes are reviewed, and a series of questions that should be addressed are outlined to guide the rational development of PARP inhibitors as anticancer agents.
Journal ArticleDOI
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
TL;DR: A special focus is placed on the known roles of distinct mono- and poly-ADP-ribosylation reactions in physiological processes, such as mitosis, cellular differentiation and proliferation, telomere dynamics, and aging, as well as “programmed necrosis” and apoptosis.
Journal ArticleDOI
Chronic health effects in people exposed to arsenic via the drinking water: dose–response relationships in review
TL;DR: Prospective studies in large area of endemic As poisoning, like Bangladesh or China, where the rate of malignancies is expected to increase within the next several decades, will help to clarify the dose-response relationship between As exposure levels and adverse health effects with enhanced accuracy.