Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies.
TLDR
Like ligands for other receptors, AhR ligands are selective AhR modulators (SAhRMs) which exhibit variable tissue-, organ- and species-specific genomic and functional activities.About:
This article is published in Current Opinion in Toxicology.The article was published on 2018-10-01 and is currently open access. It has received 43 citations till now. The article focuses on the topics: Aryl hydrocarbon receptor.read more
Citations
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Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development (dioxiny2,3,7,8-tetrachlorodibenzo-p-dioxinygene targetingyliver)
TL;DR: The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo(a)pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin this paper.
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AHR in the intestinal microenvironment: safeguarding barrier function.
TL;DR: In this article, Stockinger, Shah, and Wincent discuss AHR regulation, its role in various intestinal cell types and in intestinal inflammation and tumorigenesis, outlining the currently known physiological functions in immune, epithelial, endothelial and neuronal cells of the intestine.
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Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs).
TL;DR: Data is provided suggesting that ligands for the AhR are selective AhR modulators (SAhRMs) that exhibit tissue/cell-specific AhR agonist and antagonist activities, and that their functional diversity is similar to selective receptor modulators that target steroid hormone and other nuclear receptors.
Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities
TL;DR: The major toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) appear to result from dysregulation of mRNA levels mediated by the aryl hydrocarbon receptor (AHR).
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Kynurenine emerges from the shadows - Current knowledge on its fate and function.
Marta Marszalek-Grabska,Katarzyna Walczak,Kinga Gawel,Katarzyna Wicha-Komsta,Sylwia Wnorowska,Artur Wnorowski,Waldemar A. Turski +6 more
TL;DR: A review of the current knowledge of kynurenine fate and function can be found in this article, where the authors emphasize its importance for vital physiological and pathological processes, including inflammation and carcinogenesis.
References
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The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.
Martin van den Berg,Linda S. Birnbaum,Michael S. Denison,Mike De Vito,William H. Farland,Mark Feeley,Heidelore Fiedler,Helen Håkansson,Annika Hanberg,Laurie C. Haws,Martin Rose,Stephen Safe,Dieter Schrenk,Chiharu Tohyama,Angelika Tritscher,Jouko Tuomisto,Mats Tysklind,Nigel J. Walker,Richard E. Peterson +18 more
TL;DR: Concern was expressed about direct application of the TEF/total toxic equivalency (TEQ) approach to abiotic matrices, such as soil, sediment, etc., for direct application in human risk assessment as the present TEF scheme and TEQ methodology are primarily intended for estimating exposure and risks via oral ingestion.
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Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife
M. van den Berg,L. Birnbaum,A.T.C. Bosveld,B. Brunstrom,P. Cook,M. Feeley,John P. Giesy,Annika Hanberg,R. Hasegawa,S.W. Kennedy,T. Kubiak,J. C. Larsen,F.X.R. van Leeuwen,A. K. D. Liem,C. Nolt,R.E. Peterson,L. Poellinger,Stephen Safe,D. Schrenk,D. Tillitt,Mats Tysklind,Maged Younes,F. Waern,T. Zacharewski +23 more
TL;DR: It was concluded that the TEF concept is still the most plausible and feasible approach for risk assessment of halogenated aromatic hydrocarbons with dioxinlike properties.
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2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity
Alan Poland,Joyce C. Knutson +1 more
TL;DR: The toxicity of halogenated aromatic hydrocarbons appears to be due to the sustained expression of a normal cellular regulatory system, of which the author was previously unaware.
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Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).
TL;DR: The most toxic halogenated aromatic is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and based on in vivo and in vitro studies the relative toxicities have been determined relative to TCDD (i.e., toxic equivalents).
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and related compounds : environmental and mechanistic considerations with support the development of toxic equivalency factors (TEFs)
TL;DR: The most toxic halogenated aromatic is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as discussed by the authors.