Journal ArticleDOI
Association between body mass index and sperm quality and sperm DNA integrity. A large population study
J. B. A. Oliveira,Claudia G. Petersen,A. L. Mauri,Laura D. Vagnini,Adriana Renzi,Bruna Petersen,Mariana Mattila,Felipe Dieamant,R. L. R. Baruffi,J. G. Franco +9 more
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TLDR
Given the adverse consequences of obesity and the possible effect of male BMI on assisted reproduction technology (ART) outcomes, the benefits of weight reduction should be discussed when counselling couples interested in fertility treatment.Abstract:
Summary
This study aimed to analyse whether the functional quality of spermatozoa is associated with body mass index (BMI). Semen samples were obtained from 1824 men undergoing fertility evaluation/treatment. Semen analysis was performed using World Health Organization (WHO) criteria, and morphology was evaluated with the motile sperm organelle morphology examination (MSOME). The percentages of sperm DNA fragmentation (using TdT (terminal deoxynucleotidyl transferase)-mediated dUTP nick-end labelling (TUNEL) assays), sperm chromatin packaging/underprotamination (using chromomycin A3/CMA3), mitochondrial damage (using MitoTracker Green) and apoptosis (using annexin V) were also assessed. At least 200 spermatozoa were examined in each evaluation. The following BMI values were used as cut-off points: ≤24.9 kg/m2, 25–29.9 kg/m2 (overweight) and ≥30 kg/m2 (obese). High BMI negatively affects sperm concentration, vitality, motility and morphology (p .05). However, increased BMI is associated with increased mitochondrial damage in spermatozoa (p < .05). In conclusion, given the adverse consequences of obesity and the possible effect of male BMI on assisted reproduction technology (ART) outcomes, the benefits of weight reduction should be discussed when counselling couples interested in fertility treatment.read more
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Journal ArticleDOI
Sperm DNA Fragmentation: A New Guideline for Clinicians.
Ashok Agarwal,Ahmad Majzoub,Ahmad Majzoub,Saradha Baskaran,Manesh Kumar Panner Selvam,Chak-Lam Cho,Chak-Lam Cho,Ralf Henkel,Ralf Henkel,Renata Finelli,Kristian Leisegang,Pallav Sengupta,Catalina Barbarosie,Neel Parekh,Marco G. Alves,Edmund Y. Ko,Mohamed Arafa,Mohamed Arafa,Nicholas N. Tadros,Ranjith Ramasamy,Parviz Kavoussi,Rafael F. Ambar,Manish Kuchakulla,Kathy Amy Robert,Concetta Iovine,Damayanthi Durairajanayagam,Sunil Jindal,Rupin Shah +27 more
TL;DR: An overview of SDF types, origin and comparative analysis of various SDF assays is provided and the advantages and drawbacks of the clinical utility of S DF testing are examined using Strength-Weaknesses-Opportunities-Threats (SWOT) analysis.
Journal ArticleDOI
Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta-analysis.
Albert Salas-Huetos,Leila Maghsoumi-Norouzabad,Emma R. James,Douglas T. Carrell,Kenneth I. Aston,Timothy G. Jenkins,Timothy G. Jenkins,Nerea Becerra-Tomás,Ahmad Zare Javid,Reza Abed,Pedro Javier Torres,Pedro Javier Torres,Eugenia Mercedes Luque,Eugenia Mercedes Luque,Nicolás David Ramírez,Nicolás David Ramírez,A. C. Martini,A. C. Martini,Jordi Salas-Salvadó +18 more
TL;DR: The results suggest that maintaining a healthy body weight is important for increasing sperm quality parameters and potentially male fertility.
Journal ArticleDOI
Amelioration of diabetes-induced testicular and sperm damage in rats by cerium oxide nanoparticle treatment.
Tayebe Artimani,Iraj Amiri,Sara Soleimani Asl,Massoud Saidijam,Davood Hasanvand,Saeid Afshar +5 more
TL;DR: Overall, CNPs administration on the diabetic rates can attenuate detrimental effects of diabetes on the sperm potential fertility, sperm parameters, DNA integrity and Nrf2 expression levels.
Journal ArticleDOI
Associations of sperm DNA fragmentation with lifestyle factors and semen parameters of Saudi men and its impact on ICSI outcome.
Basmah Al Omrani,Nadia Al Eisa,Murid Javed,Maher Hassan Al Ghedan,Hamoud Al Matrafi,Hamad Al Sufyan +5 more
TL;DR: There was no difference in ICSI outcome in low and moderate sperm DNA fragmentation, however, in high spermDNA fragmentation no patient achieved pregnancy, and the results of this study indicated that 14% Saudi men had high DNA fragmentation.
Journal ArticleDOI
Sperm quality and ambient air pollution exposure: A retrospective, cohort study in a Southern province of China
TL;DR: Wang et al. as discussed by the authors used linear mixed models to evaluate the exposure-response relationship between air pollutants and semen quality, including sperm concentration, sperm count and sperm motility, after adjusting for other covariates.
References
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